Eichenauer, Dennis A. and Engert, Andreas (2021). Current treatment options for nodular lymphocyte-predominant Hodgkin lymphoma. Curr. Opin. Oncol., 33 (5). S. 395 - 400. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1531-703X

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Abstract

Purpose of review Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare B cell-derived malignancy. This review aims at providing an overview of recent developments in the management of NLPHL. Recent findings Patients with stage IA NLPHL without risk factors have excellent outcomes. The 8-year progression-free survival (PFS) is roughly 90% and the 8-year overall survival (OS) close to 100% after limited-field radiotherapy (RT) alone. Individuals presenting with early stages other than stage IA without risk factors and intermediate stages have 10-year PFS rates in excess of 70% and 10-year OS rates exceeding 90% when treated with 2 and 4 cycles of ABVD, respectively, followed by consolidation RT. In advanced NLPHL, different protocols such as BEACOPP, ABVD, and R-CHOP have been evaluated retrospectively. However, the optimal approach is undefined. Patients with relapsed NLPHL mostly receive single-agent anti-CD20 antibody treatment or conventional chemotherapy. High-dose chemotherapy and autologous stem cell transplantation are restricted to high-risk patients. NLPHL recurrence is salvaged successfully in the majority of cases. Patients with NLPHL have a very good prognosis. Treatment differs from classical Hodgkin lymphoma in some situations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Eichenauer, Dennis A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engert, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-569680
DOI: 10.1097/CCO.0000000000000774
Journal or Publication Title: Curr. Opin. Oncol.
Volume: 33
Number: 5
Page Range: S. 395 - 400
Date: 2021
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1531-703X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STEM-CELL TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; PHASE-II; RITUXIMAB; THERAPY; TRIALMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/56968

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