Universität zu Köln

Noh, Ka-Won, Buettner, Reinhard and Klein, Sebastian ORCID: 0000-0002-2188-9377 (2021). Shifting Gears in Precision Oncology-Challenges and Opportunities of Integrative Data Analysis. Biomolecules, 11 (9). BASEL: MDPI. ISSN 2218-273X

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Abstract

For decades, research relating to modification of host immunity towards antitumor response activation has been ongoing, with the breakthrough discovery of immune-checkpoint blockers. Several biomarkers with potential predictive value have been reported in recent studies for these novel therapies. However, with the plethora of therapeutic options existing for a given cancer entity, modern oncology is now being confronted with multifactorial interpretation to devise the best therapy for the individual patient. Into the bargain come the multiverse guidelines for established and emerging diagnostic biomarkers, as well as the complex interplay between cancer cells and tumor microenvironment, provoking immense challenges in the therapy decision-making process. Through this review, we present various molecular diagnostic modalities and techniques, such as genomics, immunohistochemistry and quantitative image analysis, which have the potential of becoming powerful tools in the development of an optimal treatment regime when analogized with patient characteristics. We will summarize the underlying complexities of these methods and shed light upon the necessary considerations and requirements for data integration. It is our hope to provide compelling evidence to emphasize on the need for inclusion of integrative data analysis in modern cancer therapy, and thereupon paving a path towards precision medicine and better patient outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Noh, Ka-Won UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Sebastian UNSPECIFIED orcid.org/0000-0002-2188-9377 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-572154
DOI:	10.3390/biom11091310
Journal or Publication Title:	Biomolecules
Volume:	11
Number:	9
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2218-273X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL LUNG-CANCER; MINOR HISTOCOMPATIBILITY ANTIGENS; BREAST-CANCER; AMERICAN-SOCIETY; TUMOR EVOLUTION; IMAGE-ANALYSIS; SQUAMOUS-CELL; MUTATIONS; PATHOLOGY; THERAPY Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57215