Universität zu Köln

Azimzade, Youness ORCID: 0000-0001-7363-7916 and Saberi, Abbas Ali (2021). Geometrically regulating evolutionary dynamics in biofilms. Phys. Rev. E, 103 (5). COLLEGE PK: AMER PHYSICAL SOC. ISSN 2470-0053

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Abstract

The theoretical understanding of evolutionary dynamics in spatially structured populations often relies on nonspatial models. Biofilms are among such populations where a more accurate understanding is of theoretical interest and can reveal new solutions to existing challenges. Here, we studied how the geometry of the environment affects the evolutionary dynamics of expanding populations, using the Eden model. Our results show that fluctuations of subpopulations during range expansion in two- and three-dimensional environments are not Brownian. Furthermore, we found that the substrate's geometry interferes with the evolutionary dynamics of populations that grow upon it. Inspired by these findings, we propose a periodically wedged pattern on surfaces prone to develop biofilms. On such patterned surfaces, natural selection becomes less effective and beneficial mutants would have a harder time establishing. Additionally, this modification accelerates genetic drift and leads to less diverse biofilms. Both interventions are highly desired for biofilms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Azimzade, Youness UNSPECIFIED orcid.org/0000-0001-7363-7916 UNSPECIFIED Saberi, Abbas Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-572809
DOI:	10.1103/PhysRevE.103.L050401
Journal or Publication Title:	Phys. Rev. E
Volume:	103
Number:	5
Date:	2021
Publisher:	AMER PHYSICAL SOC
Place of Publication:	COLLEGE PK
ISSN:	2470-0053
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SPATIAL STRUCTURE; GROWTH; DIVERSITY; MODELS Multiple languages Physics, Fluids & Plasmas; Physics, Mathematical Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57280