Universität zu Köln

Luetkens, Karsten Sebastian, Erguen, Sueleyman, Huflage, Henner, Kunz, Andreas Steven, Gietzen, Carsten Herbert, Conrads, Nora, Pennig, Lenhard, Goertz, Lukas, Bley, Thorsten Alexander, Gassenmaier, Tobias ORCID: 0000-0002-1089-2036 and Grunz, Jan-Peter (2021). Dose reduction potential in cone-beam CT imaging of upper extremity joints with a twin robotic x-ray system. Sci Rep, 11 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

Cone-beam computed tomography is a powerful tool for 3D imaging of the appendicular skeleton, facilitating detailed visualization of bone microarchitecture. This study evaluated various combinations of acquisition and reconstruction parameters for the cone-beam CT mode of a twin robotic x-ray system in cadaveric wrist and elbow scans, aiming to define the best possible trade-off between image quality and radiation dose. Images were acquired with different combinations of tube voltage and tube current-time product, resulting in five scan protocols with varying volume CT dose indices: full-dose (FD; 17.4 mGy), low-dose (LD; 4.5 mGy), ultra-low-dose (ULD; 1.15 mGy), modulated low-dose (mLD; 0.6 mGy) and modulated ultra-low-dose (mULD; 0.29 mGy). Each set of projection data was reconstructed with three convolution kernels (very sharp [Ur77], sharp [Br69], intermediate [Br62]). Five radiologists subjectively assessed the image quality of cortical bone, cancellous bone and soft tissue using seven-point scales. Irrespective of the reconstruction kernel, overall image quality of every FD, LD and ULD scan was deemed suitable for diagnostic use in contrast to mLD (very sharp/sharp/intermediate: 60/55/70%) and mULD (0/3/5%). Superior depiction of cortical and cancellous bone was achieved in FDUr77 and LDUr77 examinations (p < 0.001) with LDUr77 scans also providing favorable bone visualization compared to FDBr69 and FDBr62 (p < 0.001). Fleiss' kappa was 0.618 (0.594-0.641; p < 0.001), indicating substantial interrater reliability. In this study, we demonstrate that considerable dose reduction can be realized while maintaining diagnostic image quality in upper extremity joint scans with the cone-beam CT mode of a twin robotic x-ray system. Application of sharper convolution kernels for image reconstruction facilitates superior display of bone microarchitecture.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Luetkens, Karsten Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Erguen, Sueleyman UNSPECIFIED UNSPECIFIED UNSPECIFIED Huflage, Henner UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunz, Andreas Steven UNSPECIFIED UNSPECIFIED UNSPECIFIED Gietzen, Carsten Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Conrads, Nora UNSPECIFIED UNSPECIFIED UNSPECIFIED Pennig, Lenhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Goertz, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bley, Thorsten Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Gassenmaier, Tobias UNSPECIFIED orcid.org/0000-0002-1089-2036 UNSPECIFIED Grunz, Jan-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576030
DOI:	10.1038/s41598-021-99748-1
Journal or Publication Title:	Sci Rep
Volume:	11
Number:	1
Date:	2021
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPUTED-TOMOGRAPHY; EPIDEMIOLOGY; FORMALIN; FRACTURE; OUTCOMES Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57603