Kron, F., Franz, J., Kron, A. and Hallek, M. (2021). Economics and management of CAR T- cell therapy Status quo and future perspectives. Internist, 62 (6). S. 620 - 627. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1289

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Abstract

Background Virtually no other topic has attracted more attention in oncology in recent years than chimeric antigen receptor (CAR) T-cell therapy (CAR T). On the one hand it opens up completely new treatment options for cancer patients, while on the other it generates treatment costs exceeding euro 300,000 per treatment. Objectives The aim of this work is to analyze the economic, procedural and organizational challenges of CAR T-cell therapy from the perspective of the service provider, the cost-bearer and the pharmaceutical manufacturer. Material and methods The current German diagnosis-related-group (G-DRG) catalog, the G-DRG tariff, of the German Federal Joint Committee (G-BA) guidelines and G-DRG coding principles were used to evaluate the reimbursement and remuneration system in Germany. Practical experiences of medical sites were integrated in the analysis. Results The findings demonstrate great economic challenges especially from the perspective of a CAR T site. Increasing certification and qualification efforts lead to financial pressure. Insufficient reimbursement and inadequate cost-covering for CAR T treatment result in budget restrictions for hospitals. Conclusion High drug costs as well as enormous personnel and infrastructural requirements demand transparent and sufficient reimbursement for hospitals. Interaction between hospital and pharmaceutical manufacturer in the CAR T process might enable new means of cooperation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kron, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franz, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kron, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hallek, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-576736
DOI: 10.1007/s00108-021-01042-9
Journal or Publication Title: Internist
Volume: 62
Number: 6
Page Range: S. 620 - 627
Date: 2021
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1432-1289
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57673

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