Universität zu Köln

Proescholdt, Martin, Junger, Stephanie T., Schodel, Petra, Schebesch, Karl-Michael, Doenitz, Christian, Pukrop, Tobias, Hohne, Julius, Schmidt, Nils-Ole, Kocher, Martin ORCID: 0000-0002-5674-9227, Schulz, Holger, Ruge, Maximilian, Konig, Kevin, Goldbrunner, Roland and Grau, Stefan ORCID: 0000-0002-9742-527X (2021). Brain Metastases in Elderly Patients-The Role of Surgery in the Context of Systemic Treatment. Brain Sci., 11 (1). BASEL: MDPI. ISSN 2076-3425

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Abstract

In patients with brain metastases (BM), advanced age is considered a negative prognostic factor. To address the potential reasons for that, we assessed 807 patients who had undergone BM resection; 315 patients aged at least 65 years (group A) were compared with 492 younger patients (group B). We analyzed the impact of the pre- and postoperative Karnofsky performance status (KPS), postoperative treatment structure and post-treatment survival. BM resection significantly improved KPS scores in both groups (p = 0.0001). Median survival after BM resection differed significantly between the groups (A: 5.81 vs. B: 8.12 months; p = 0.0015). In both groups, patients who received postoperative systemic treatment showed significantly longer overall survival (p = 0.00001). However, elderly patients less frequently received systemic treatment (p = 0.0001) and the subgroup of elderly patients receiving such therapies had a significantly higher postsurgical KPS score (p = 0.0007). In all patients receiving systemic treatment, age was no longer a negative prognostic factor. Resection of BM improves the functional status of elderly patients, thus enhancing the likeliness to receive systemic treatment, which, in turn, leads to longer overall survival. In the context of such a treatment structure, age alone is no longer a prognostic factor for survival.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Proescholdt, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Junger, Stephanie T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schodel, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Schebesch, Karl-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Doenitz, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Pukrop, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hohne, Julius UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Nils-Ole UNSPECIFIED UNSPECIFIED UNSPECIFIED Kocher, Martin UNSPECIFIED orcid.org/0000-0002-5674-9227 UNSPECIFIED Schulz, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruge, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Konig, Kevin UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Grau, Stefan UNSPECIFIED orcid.org/0000-0002-9742-527X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-577550
DOI:	10.3390/brainsci11010123
Journal or Publication Title:	Brain Sci.
Volume:	11
Number:	1
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3425
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57755