Universität zu Köln

Reimer, Robert Peter, Klein, Konstantin, Rinneburger, Miriam ORCID: 0000-0003-3980-931X, Zopfs, David, Lennartz, Simon ORCID: 0000-0002-3254-4809, Salem, Johannes, Heidenreich, Axel, Maintz, David, Haneder, Stefan and Hokamp, Nils Grosse (2021). Manual kidney stone size measurements in computed tomography are most accurate using multiplanar image reformatations and bone window settings. Sci Rep, 11 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

Computed tomography in suspected urolithiasis provides information about the presence, location and size of stones. Particularly stone size is a key parameter in treatment decision; however, data on impact of reformatation and measurement strategies is sparse. This study aimed to investigate the influence of different image reformatations, slice thicknesses and window settings on stone size measurements. Reference stone sizes of 47 kidney stones representative for clinically encountered compositions were measured manually using a digital caliper (Man-M). Afterwards stones were placed in a 3D-printed, semi-anthropomorphic phantom, and scanned using a low dose protocol (CTDIvol 2 mGy). Images were reconstructed using hybrid-iterative and model-based iterative reconstruction algorithms (HIR, MBIR) with different slice thicknesses. Two independent readers measured largest stone diameter on axial (2 mm and 5 mm) and multiplanar reformatations (based upon 0.67 mm reconstructions) using different window settings (soft-tissue and bone). Statistics were conducted using ANOVA +/- correction for multiple comparisons. Overall stone size in CT was underestimated compared to Man-M (8.8 +/- 2.9 vs. 7.7 +/- 2.7 mm, p < 0.05), yet closely correlated (r = 0.70). Reconstruction algorithm and slice thickness did not significantly impact measurements (p > 0.05), while image reformatations and window settings did (p < 0.05). CT measurements using multiplanar reformatation with a bone window setting showed closest agreement with Man-M (8.7 +/- 3.1 vs. 8.8 +/- 2.9 mm, p < 0.05, r = 0.83). Manual CT-based stone size measurements are most accurate using multiplanar image reformatation with a bone window setting, while measurements on axial planes with different slice thicknesses underestimate true stone size. Therefore, this procedure is recommended when impacting treatment decision.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reimer, Robert Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Konstantin UNSPECIFIED UNSPECIFIED UNSPECIFIED Rinneburger, Miriam UNSPECIFIED orcid.org/0000-0003-3980-931X UNSPECIFIED Zopfs, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Lennartz, Simon UNSPECIFIED orcid.org/0000-0002-3254-4809 UNSPECIFIED Salem, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hokamp, Nils Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-577848
DOI:	10.1038/s41598-021-95962-z
Journal or Publication Title:	Sci Rep
Volume:	11
Number:	1
Date:	2021
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ITERATIVE RECONSTRUCTION; CT; VOLUME; QUANTIFICATION; UROLITHIASIS; AGREEMENT; DISEASE; MODEL Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57784