Universität zu Köln

Matthaei, M., Hos, D., Bock, F., Le, V. N. H., Hou, Y., Schaub, F., Siebelmann, S., Zhang, W., Roters, S., Bachmann, B. O. and Cursiefen, C. (2021). Preconditioning of vascularized high-risk eyes using fine-needle diathermy and cross-linking. Ophthalmologe, 118 (6). S. 553 - 561. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0423

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Abstract

Background The risk of allograft rejection following high-risk keratoplasty increases with the area of corneal neovascularization. Pharmaceutical and physical regression of corneal neovascularization before keratoplasty may offer the potential to reduce the risk of graft rejection after high-risk keratoplasty. Objective This article provides a review of the literature on the preconditioning of vascularized high-risk eyes using fine-needle diathermy and corneal cross-linking (preoperative preconditioning by lymphangioregression). Methods A literature search was carried out in PubMed and a summary of own data is presented. Results Animal experimental studies showed that both fine-needle diathermy and corneal cross-linking lead to a regression of corneal neovascularization and prolong graft survival after high-risk keratoplasty. Furthermore, studies from our institute provide first evidence that both procedures also lead to a reduction of corneal neovascularization in the clinical practice and thus potentially reduce the risk of allograft rejection after subsequent high-risk keratoplasty. Discussion Fine-needle diathermy and corneal cross-linking provide effective therapeutic approaches for angioregressive treatment and seem to prolong graft survival following high-risk keratoplasty. Larger prospective and controlled clinical trials are needed to further investigate these promising therapeutic approaches.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Matthaei, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hos, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bock, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Le, V. N. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hou, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaub, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebelmann, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roters, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, B. O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-579927
DOI:	10.1007/s00347-021-01415-3
Journal or Publication Title:	Ophthalmologe
Volume:	118
Number:	6
Page Range:	S. 553 - 561
Date:	2021
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0423
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOTHELIAL GROWTH-FACTOR; IMPROVES GRAFT-SURVIVAL; CORNEAL NEOVASCULARIZATION; TERM; KERATOPLASTY; KERATITIS; LYMPHANGIOGENESIS; TRANSPLANTATION; ANGIOGENESIS; KERATOCONUS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57992