Universität zu Köln

Azimzade, Youness ORCID: 0000-0001-7363-7916, Saberi, Abbas Ali and Gatenby, Robert A. (2021). Superlinear growth reveals the Allee effect in tumors. Phys. Rev. E, 103 (4). COLLEGE PK: AMER PHYSICAL SOC. ISSN 2470-0053

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Abstract

Integrating experimental data into ecological models plays a central role in understanding biological mechanisms that drive tumor progression where such knowledge can be used to develop new therapeutic strategies. While the current studies emphasize the role of competition among tumor cells, they fail to explain recently observed superlinear growth dynamics across human tumors. Here we study tumor growth dynamics by developing a model that incorporates evolutionary dynamics inside tumors with tumor-microenvironment interactions. Our results reveal that tumor cells' ability to manipulate the environment and induce angiogenesis drives superlinear growth-a process compatible with the Allee effect. In light of this understanding, our model suggests that, for high-risk tumors that have a higher growth rate, suppressing angiogenesis can be the appropriate therapeutic intervention.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Azimzade, Youness UNSPECIFIED orcid.org/0000-0001-7363-7916 UNSPECIFIED Saberi, Abbas Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Gatenby, Robert A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-581040
DOI:	10.1103/PhysRevE.103.042405
Journal or Publication Title:	Phys. Rev. E
Volume:	103
Number:	4
Date:	2021
Publisher:	AMER PHYSICAL SOC
Place of Publication:	COLLEGE PK
ISSN:	2470-0053
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PASSENGER MUTATIONS; CANCER; CELL; EVOLUTION; DYNAMICS; MODEL; INVASION; DRIVER; PROLIFERATION; MATHEMATICS Multiple languages Physics, Fluids & Plasmas; Physics, Mathematical Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58104