Scherner, M., Weber, C., Schmidt, H., Kuhr, K., Hamacher, S., Sabashnikov, A., Eghbalzadeh, K., Mader, N., Wahlers, T. and Wippermann, J. (2022). Impact of urgent coronary artery bypass grafting on acute kidney injury A matched cohort study. Med Klin Intensivmed Notfmed, 117 (2). S. 152 - 159. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2193-6226

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Abstract

Objectives There is limited knowledge regarding the specific interrelationships between urgent coronary artery bypass graft (U-CABG) surgery and postoperative acute kidney injury (AKI). We aimed to (1) analyze the impact of urgent CABG (U-CABG) on the incidence and severity of postoperative AKI, (2) estimate the influence of AKI after U-CABG or elective CABG (E-CABG) on mortality and (3) identify risk factors for AKI depending on the urgency of operation. Results U-CABG patients showed a higher incidence of AKI (49.8% vs. E-CABG: 39.7%; p = 0.026), especially for higher AKI stages 2 + 3. In-hospital mortality was higher in U-CABG patients (12.6%) compared to E-CABG patients (2.3%; p < 0.001). The impact of AKI on mortality did not differ, but showed a strong coherency between higher AKI stages (2 + 3) and mortality (stage 1: OR 2.409, 95% CI 1.017-5.706; p = 0.046 vs. stage 2 + 3: OR 5.577; 95% CI 2.033-15.3; p = 0.001). Univariate logistic regression analysis revealed that preoperative renal impairment, peripheral vascular disease and transfusion of more than two red blood cell concentrates were predictors for postoperative AKI in both groups. Conclusions U-CABG is a risk factor for postoperative AKI and even mild AKI leads to a significantly higher mortality. Hence, the prevention of modifiable risk factors might reduce the incidence of postoperative AKI and thus improve outcome.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Scherner, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhr, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamacher, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabashnikov, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eghbalzadeh, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mader, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wahlers, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wippermann, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-583285
DOI: 10.1007/s00063-020-00769-x
Journal or Publication Title: Med Klin Intensivmed Notfmed
Volume: 117
Number: 2
Page Range: S. 152 - 159
Date: 2022
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 2193-6226
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58328

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