Universität zu Köln

Wunram, Heidrun Lioba ORCID: 0000-0002-9140-6000, Oberste, Max, Hamacher, Stefanie ORCID: 0000-0003-2158-9101, Neufang, Susanne, Grote, Nils, Krischer, Maya Kristina, Bloch, Wilhelm, Schoenau, Eckhard, Bender, Stephan and Fricke, Oliver ORCID: 0000-0001-7592-8653 (2021). Immunological Effects of an Add-On Physical Exercise Therapy in Depressed Adolescents and Its Interplay with Depression Severity. Int. J. Environ. Res. Public Health, 18 (12). BASEL: MDPI. ISSN 1660-4601

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Abstract

Background: Pro-inflammatory cytokines (PICs) have gained attention in the pathophysiology and treatment of depressive disorders. At the same time, the therapeutic effect of physical activity seems to work via immunomodulatory pathways. The interventional study Mood Vibes analyzed the influence of exercise on depression severity (primary endpoint) in depressive adolescents; the influence of PICs on the clinical outcome was analyzed as a secondary endpoint. Methods: Clinically diagnosed depressed adolescents (N = 64; 28.1% male; mean age = 15.9; mean BMI = 24.6) were included and participated either in Whole Body Vibration (WBV) (n = 21) or bicycle ergometer training (n = 20) in addition to treatment-as-usual (TAU). Patients in the control treatment group received TAU only (n = 23). The PICs (interleukin-6-IL-6 and tumor necrosis factor-alpha-TNF-alpha) were analyzed before intervention, after 6 weeks of training (t1), and 8 weeks post-intervention (t2). The effects of the treatment on depression severity were rated by self-rating Depression Inventory for Children and Adolescents (DIKJ). Results: Basal IL-6 decreased in all groups from t0 to t1, but it increased again in WBV and controls at t2. TNF-alpha diminished in ergometer and controls from baseline to t1. PIC levels showed no correlation with depression severity at baseline. The influence on DIKJ scores over time was significant for IL-6 in the WBV group (p = 0.008). Sex had an impact on TNF-alpha (p < 0.001), with higher concentrations in male patients. Higher body mass index was associated with higher IL-6 concentrations over all measurement points (p < 0.001). Conclusions: The positive effects of an intensive add-on exercise therapy on adolescent depression seem to be partly influenced by immunomodulation. A small sample size and non-randomized controls are limitations of this study.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wunram, Heidrun Lioba UNSPECIFIED orcid.org/0000-0002-9140-6000 UNSPECIFIED Oberste, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamacher, Stefanie UNSPECIFIED orcid.org/0000-0003-2158-9101 UNSPECIFIED Neufang, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Grote, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Krischer, Maya Kristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Fricke, Oliver UNSPECIFIED orcid.org/0000-0001-7592-8653 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-584452
DOI:	10.3390/ijerph18126527
Journal or Publication Title:	Int. J. Environ. Res. Public Health
Volume:	18
Number:	12
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1660-4601
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WHOLE-BODY VIBRATION; PRO-INFLAMMATORY CYTOKINES; NECROSIS-FACTOR-ALPHA; MAJOR DEPRESSION; MENTAL-HEALTH; CHILDREN; IMMUNE; INTERLEUKIN-6; SYMPTOMS; DISORDERS Multiple languages Environmental Sciences; Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58445