Universität zu Köln

Schorn, Lara ORCID: 0000-0002-4301-0693, Fienitz, Tim, De Donno, Francesco, Sterner-Kock, Anja, Maul, Alexandra C., Holtmann, Henrik ORCID: 0000-0003-1477-6400, Lommen, Julian and Rothamel, Daniel (2021). Critical-size Defect Augmentation Using Sintered and Non-Sintered Bovine Bone Matrix - An Experimental Controlled Study in Minipigs. J. Oral Maxillofac. Surg., 79 (9). S. 1866 - 1874. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. ISSN 1531-5053

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Abstract

Purpose: Xenogeneic bone substitute materials are often used for augmentation of larger bone defects. Purification methods for these materials vary, mainly in terms of temperature. The aim of this study was to determine in vivo how sintering affects quantitative and qualitative bone regeneration of 2 bovine augmentation materials. Methods: A total of 56 critical size defects were set at the frontal bone of 14 domestic pigs (4 each) and filled randomly with either bovine, sintered hydroxyapatite (BO), bovine, non-sintered hydroxyapatite (BOS), local autologous bone (AB) or left empty. All defects were additionally covered with a collagen membrane. Specimens were harvested after 4 and 8 weeks and were evaluated histologically and histomorphometrically. Results: Histologically new bone could be seen in every group. Significantly highest new bone formation was found in AB. No significant difference could be detected between BO and BOS. Conclusions: According to the results of this study, sintered bone substitute material remains histologically distinguishable but does not affect quantitative and qualitative bone regeneration. (C) 2021 The American Association of Oral and Maxillofacial Surgeons.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schorn, Lara UNSPECIFIED orcid.org/0000-0002-4301-0693 UNSPECIFIED Fienitz, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED De Donno, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Sterner-Kock, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Maul, Alexandra C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtmann, Henrik UNSPECIFIED orcid.org/0000-0003-1477-6400 UNSPECIFIED Lommen, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothamel, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-586019
DOI:	10.1016/j.joms.2021.03.025
Journal or Publication Title:	J. Oral Maxillofac. Surg.
Volume:	79
Number:	9
Page Range:	S. 1866 - 1874
Date:	2021
Publisher:	W B SAUNDERS CO-ELSEVIER INC
Place of Publication:	PHILADELPHIA
ISSN:	1531-5053
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MULTINUCLEATED GIANT-CELLS; ALVEOLAR RIDGE; PHYSICOCHEMICAL CHARACTERIZATION; SUBSTITUTES; GRAFT; RECONSTRUCTION; REGENERATION; XENOGRAFTS Multiple languages Dentistry, Oral Surgery & Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58601