Universität zu Köln

Oezcueruemez, Mustafa, Arzideh, Farhad, Torge, Antje, Figge, Anja, Haeckel, Rainer and Streichert, Thomas (2021). The influence of sampling time on indirect reference limits, decision limits, and the estimation of biological variation of random plasma glucose concentrations. J. Lab. Med., 45 (2). S. 111 - 120. BERLIN: WALTER DE GRUYTER GMBH. ISSN 2567-9449

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Abstract

Objectives: Plasma glucose concentrations exhibit a pronounced daytime-dependent variation. The oscillations responsible for this are currently not considered in the determination of reference limits (RL) and decision limits. Methods: We characterized the daily variation inherent in large-scale laboratory data from two different university hospitals (site 1 n=513,682, site 2 n=204,001). Continuous and distinct RL for daytime and night were estimated. Diurnal characteristics of glucose concentrations were further investigated by quantile regression analyses introducing age and cosinor-functions as predictors in the model. Results: Diurnal variations expressed as amplitude/Midline Estimating Statistic of Rhythm (MESOR) ratio, averaged 7.7% (range 5.9-9.3%). The amplitude of glucose levels decreased with increasing concentrations. Between 06:00 and 10:00 h an average decrease of 4% has to be considered. Nocturnal glucose samples accounted for only 5% of the total amount but contributed to 19.5% of all findings over 11.1 mmol/L. Partitioning of RL between day and night is merely justified for the upper reference limit. The nocturnal upper RLs for both genders differed from those obtained during the day by 11.0 and 10.6% at site 1 and by 7.6 and 7.5% at site 2. Conclusions: We conclude that indirect approaches to estimate upper RL of random plasma glucose concentrations require stratification concerning the time of sample collection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Oezcueruemez, Mustafa UNSPECIFIED UNSPECIFIED UNSPECIFIED Arzideh, Farhad UNSPECIFIED UNSPECIFIED UNSPECIFIED Torge, Antje UNSPECIFIED UNSPECIFIED UNSPECIFIED Figge, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Haeckel, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Streichert, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-586447
DOI:	10.1515/labmed-2020-0146
Journal or Publication Title:	J. Lab. Med.
Volume:	45
Number:	2
Page Range:	S. 111 - 120
Date:	2021
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	2567-9449
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REFERENCE INTERVALS Multiple languages Medical Laboratory Technology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58644