Universität zu Köln

Wagner, Isabel Viola, Oliver, Elizabeth, Doetsch, Joerg and Soeder, Olle (2021). Adverse effects of metabolic disorders in childhood on adult reproductive function and fertility in the male. J. Pediatr. Endocrinol. Metab., 34 (1). S. 13 - 24. BERLIN: WALTER DE GRUYTER GMBH. ISSN 2191-0251

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Abstract

Over the last 50 years, there has been a steady decline in fertility rates in humans, which has occurred in parallel with an increasing incidence of obesity and metabolic disorders. The potential impact of these disorders and plausible mechanisms by which they negatively influence male reproduction are only partly understood and published data are often controversial. Obesity is one of the most important health challenges worldwide and is becoming more prevalent in children and adolescents. Obesity, the metabolic syndrome and related comorbidities can lead to impaired male reproductive function, including adverse effects on spermatogenesis and steroidogenesis as illustrated by reduced sperm number and quality, decreased testosterone levels and elevated inflammatory markers. The incidence of diabetes mellitus type I is also dramatically increasing and may negatively impact spermatogenesis and testicular function, resulting in decreased serum testosterone and epididymal weight. In this review, we summarize and discuss the effects of metabolic diseases that typically develop during childhood and adolescence on later reproductive function and fertility. While impact on reproductive health is likely observed in both sexes, we have chosen to focus on the male in the current review. Specifically, we illustrate adverse effects of obesity, type 1 diabetes, the metabolic syndrome and insulin resistance on sperm function and testosterone metabolism. Identification of pathophysiological mechanisms during childhood may open up new avenues for early prevention and treatment resulting in better reproductive outcomes and improved fertility rates during adulthood.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wagner, Isabel Viola UNSPECIFIED UNSPECIFIED UNSPECIFIED Oliver, Elizabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Soeder, Olle UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-586753
DOI:	10.1515/jpem-2020-0276
Journal or Publication Title:	J. Pediatr. Endocrinol. Metab.
Volume:	34
Number:	1
Page Range:	S. 13 - 24
Date:	2021
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	2191-0251
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIABETES-MELLITUS; LUTEINIZING-HORMONE; TESTICULAR STEROIDOGENESIS; INDUCED HYPERGLYCEMIA; OXIDATIVE STRESS; CELL FUNCTION; LEYDIG-CELLS; RAT TESTES; LEPTIN; INSULIN Multiple languages Endocrinology & Metabolism; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58675