Universität zu Köln

Molinnus, Denise, Drinic, Aleksander, Iken, Heiko ORCID: 0000-0002-2733-5105, Kroeger, Nadja, Zinser, Max, Smeets, Ralf, Koepf, Marius, Kopp, Alexander ORCID: 0000-0001-8787-0401 and Schoening, Michael J. ORCID: 0000-0003-4347-6685 (2021). Towards a flexible electrochemical biosensor fabricated from biocompatible Bombyx mori silk. Biosens. Bioelectron., 183. OXFORD: ELSEVIER ADVANCED TECHNOLOGY. ISSN 1873-4235

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Abstract

In modern days, there is an increasing relevance of and demand for flexible and biocompatible sensors for in-vivo and epidermal applications. One promising strategy is the implementation of biological (natural) polymers, which offer new opportunities for flexible biosensor devices due to their high biocompatibility and adjustable biodegradability. As a proof-of-concept experiment, a biosensor was fabricated by combining thin- (for Pt working- and counter electrode) and thick-film (for Ag/AgCl quasi-reference electrode) technologies: The biosensor consists of a fully bio-based and biodegradable fibroin substrate derived from silk fibroin of the silkworm Bombyx mori combined with immobilized enzyme glucose oxidase. The flexible glucose biosensor is encapsulated by a biocompatible silicon rubber which is certificated for a safe use onto human skin. Characterization of the sensor set-up is exemplarily demonstrated by glucose measurements in buffer and Ringer?s solution, while the stability of the quasi-reference electrode has been investigated versus a commercial Ag/AgCl reference electrode. Repeated bending studies validated the mechanical properties of the electrode structures. The cross-sensitivity of the biosensor against ascorbic acid, noradrenaline and adrenaline was investigated, too. Additionally, biocompatibility and degradation tests of the silk fibroin with and without thin-film platinum electrodes were carried out.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Molinnus, Denise UNSPECIFIED UNSPECIFIED UNSPECIFIED Drinic, Aleksander UNSPECIFIED UNSPECIFIED UNSPECIFIED Iken, Heiko UNSPECIFIED orcid.org/0000-0002-2733-5105 UNSPECIFIED Kroeger, Nadja UNSPECIFIED UNSPECIFIED UNSPECIFIED Zinser, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Smeets, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Koepf, Marius UNSPECIFIED UNSPECIFIED UNSPECIFIED Kopp, Alexander UNSPECIFIED orcid.org/0000-0001-8787-0401 UNSPECIFIED Schoening, Michael J. UNSPECIFIED orcid.org/0000-0003-4347-6685 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-589347
DOI:	10.1016/j.bios.2021.113204
Journal or Publication Title:	Biosens. Bioelectron.
Volume:	183
Date:	2021
Publisher:	ELSEVIER ADVANCED TECHNOLOGY
Place of Publication:	OXFORD
ISSN:	1873-4235
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUASI-REFERENCE ELECTRODE; IMPLANTABLE GLUCOSE SENSORS; FIBROIN PROTEIN; ASCORBIC-ACID; DEGRADATION; DEVICES; BIODEGRADATION; VOLTAMMETRY; COMPOSITE; INJECTION Multiple languages Biophysics; Biotechnology & Applied Microbiology; Chemistry, Analytical; Electrochemistry; Nanoscience & Nanotechnology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58934