Adebayo, Oyindamola Christiana ORCID: 0000-0001-5076-9983, Betukumesu, DieuMerci Kabasele, Nkoy, Agathe Bikupe, Adesoji, Oluyomi Modupe, Ekulu, Pepe Mfutu, Van den Heuvel, Lambertus P., Levtchenko, Elena N. and Labarque, Veerle (2022). Clinical and genetic factors are associated with kidney complications in African children with sickle cell anaemia. Br. J. Haematol., 196 (1). S. 204 - 215. HOBOKEN: WILEY. ISSN 1365-2141

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Abstract

Clinical and genetic factors have been reported as influencing the development of sickle cell nephropathy (SCN). However, such data remain limited in the paediatric population. In this cross-sectional study, we enrolled 361 sickle cell disease children from the Democratic Republic of Congo. Participants were genotyped for the beta (beta)-globin gene, apolipoprotein L1 (APOL1) risk variants, and haem oxygenase-1 (HMOX1) GT-dinucleotide repeats. As markers of kidney damage, albuminuria, hyperfiltration and decreased estimated glomerular filtration with creatinine (eGFRcr) were measured. An association of independent clinical and genetic factors with these markers of kidney damage were assessed via regression analysis. Genetic sequencing confirmed sickle cell anaemia in 326 participants. Albuminuria, hyperfiltration and decreased eGFRcr were present in 65 (20%), 52 (16%) and 18 (5 center dot 5%) patients, respectively. Regression analysis revealed frequent blood transfusions, indirect bilirubin and male gender as clinical predictors of SCN. APOL1 high-risk genotype (G1/G1, G2/G2 and G1/G2) was significantly associated with albuminuria (P = 0 center dot 04) and hyperfiltration (P = 0 center dot 001). HMOX1 GT-dinucleotide long repeats were significantly associated with lower eGFRcr. The study revealed a high burden of kidney damage among Congolese children and provided evidence of the possible role of APOL1 and HMOX1 in making children more susceptible to kidney complications.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Adebayo, Oyindamola ChristianaUNSPECIFIEDorcid.org/0000-0001-5076-9983UNSPECIFIED
Betukumesu, DieuMerci KabaseleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nkoy, Agathe BikupeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adesoji, Oluyomi ModupeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ekulu, Pepe MfutuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van den Heuvel, Lambertus P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Levtchenko, Elena N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Labarque, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-589913
DOI: 10.1111/bjh.17832
Journal or Publication Title: Br. J. Haematol.
Volume: 196
Number: 1
Page Range: S. 204 - 215
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1365-2141
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RENAL-FUNCTION; GLOMERULAR HYPERFILTRATION; DISEASE; PREVALENCE; ALBUMINURIA; HEMOGLOBIN; ADULTS; MICROALBUMINURIA; PROGRESSION; APOL1Multiple languages
HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58991

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