Seifert, Georg, Funk, Petra, Reineke, Thorsten and Lehmacher, Walter (2021). Influence of EPs 7630 on Antipyretic Comedication and Recovery from Acute Tonsillopharyngitis in Children: A Meta-analysis of Randomized, Placebo-Controlled, Clinical Trials. J. Pediatr. Infect. Dis., 16 (3). S. 122 - 129. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1305-7693

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Abstract

Objective Acute tonsillopharyngitis (ATP) is a common, seasonal infection of predominantly viral origin. Management is aimed at shortening the course of the disease and restoring the comfort of the patient. We performed a meta-analysis to investigate whether treatment with the Pelargonium sidoides extract EPs 7630 reduces the use of antipyretic comedication (i.e., acetaminophen) in children suffering from ATP. Methods Studies were identified from clinical trial registries and medical literature. Randomized, placebo-controlled, clinical trials investigating EPs 7630 in children with ATP and reporting the coadministration of paracetamol were eligible. Based on the raw data of eligible trials, we analyzed cumulative paracetamol use, as well as the ability to attend school at the end of treatment. Three trials including a total of 345 children aged 6 to 10 years and suffering from non-beta -hemolytic streptococcal ATP were identified and eligible. Children were administered EPs 7630 or placebo for 6 days. Results Compared with placebo, EPs 7630 reduced the cumulative paracetamol dose by an average of 449mg (95% confidence interval [CI]: 252-646mg; p <0.001). A total of 19.1% (EPs 7630) and 71.5% (placebo) of children were still unable to attend school at the end of the treatment (risk ratio=0.28; 95% CI: 0.16-0.48; p <0.001). Conclusion Our meta-analysis demonstrates that EPs 7630 reduced the use of antipyretic comedication and accelerated recovery.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Seifert, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Funk, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reineke, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmacher, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-590156
DOI: 10.1055/s-0040-1722205
Journal or Publication Title: J. Pediatr. Infect. Dis.
Volume: 16
Number: 3
Page Range: S. 122 - 129
Date: 2021
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1305-7693
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GROUP A-STREPTOCOCCI; RESPIRATORY-TRACT INFECTIONS; HERBAL DRUG PREPARATION; PELARGONIUM-SIDOIDES; DOUBLE-BLIND; ACUTE BRONCHITIS; IN-VITRO; EXTRACT; EFFICACY; PHARYNGITISMultiple languages
Infectious Diseases; PediatricsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59015

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