Gravity and Mastoid Effusion - Kölner UniversitätsPublikationsServer

Lecheler, Leopold, Paulke, Freia, Sonnow, Lena, Limper, Ulrich, Schwarz, David ORCID: 0000-0002-4580-8383, Jansen, Stefanie, Klussmann, Jens Peter ORCID: 0000-0002-8223-7954, Tank, Jens ORCID: 0000-0002-5672-1187 and Jordan, Jens ORCID: 0000-0003-4518-0706 (2021). Gravity and Mastoid Effusion. Am. J. Med., 134 (3). S. E181 - 3. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1555-7162

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DOI:10.1016/j.amjmed.2020.09.020

Abstract

BACKGROUND: Asymptomatic mastoid effusions have recently been observed in astronauts returning from long-term spaceflight. In hospitalized patients, mastoid effusion increases the risks for bacterial otitis and mastoiditis. We reasoned that cephalad fluid shifts during strict -6 degrees head down tilt bed rest could reproduce space-flight associated mastoid effusion and that artificial gravity may reverse the response. METHODS: The recent Artificial Gravity Bed Rest Study-European Space Agency study (AGBRESA) tested influences of artificial gravity during 60 days head down bed rest on a short-arm human centrifuge in healthy participants. The two intervention groups received daily artificial gravity with 30 minutes continuous artificial gravity or intermittent artificial gravity. A third group served as a control group and received no artificial gravity. We assessed cranial magnetic resonance images for mastoid effusions 1 day before bed rest, at days 14 and 52 of bed rest, and 3 days after bed rest. RESULTS: None of the participants exhibited mastoid effusions before bed rest. Six participants showed mastoid effusions at bed rest day 14 (4 continuous, 2 intermittent, 0 control). Fifteen participants showed mastoid effusions at bed rest day 52 and 3 days after bed rest (7 continuous, 3 intermittent, 5 control). CONCLUSIONS: Mastoid effusions commonly occur during strict head down tilt bed rest. The model can be applied to study the mechanisms and potential countermeasures for space flight-associated mastoid effusions. Formation of mastoid effusions during head down tilt bed rest is not prevented by daily 30 minutes short-arm intermittent or continuous centrifugation. (C) 2020 Elsevier Inc. All rights reserved.

Item Type:

Journal Article

Creators:

Creators	Email	ORCID	ORCID Put Code
Lecheler, Leopold	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Paulke, Freia	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Sonnow, Lena	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Limper, Ulrich	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Schwarz, David	UNSPECIFIED	orcid.org/0000-0002-4580-8383	UNSPECIFIED
Jansen, Stefanie	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Klussmann, Jens Peter	UNSPECIFIED	orcid.org/0000-0002-8223-7954	UNSPECIFIED
Tank, Jens	UNSPECIFIED	orcid.org/0000-0002-5672-1187	UNSPECIFIED
Jordan, Jens	UNSPECIFIED	orcid.org/0000-0003-4518-0706	UNSPECIFIED