Universität zu Köln

Schoenknecht, Yannik Bernd, Crommen, Silke, Stoffel-Wagner, Birgit, Coenen, Martin, Fimmers, Rolf, Stehle, Peter ORCID: 0000-0002-4596-8088, Ramirez, Alfredo ORCID: 0000-0003-4991-763X and Egert, Sarah (2021). APOE e4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits. Nutrients, 13 (11). BASEL: MDPI. ISSN 2072-6643

Full text not available from this repository.

Abstract

The apolipoprotein E (APOE) polymorphism impacts blood lipids and biomarkers of oxidation and inflammation, contributing to an isoform-dependent disease risk. We investigated the effect of the APOE genotype on postprandial metabolism after consumption of three different isoenergetic (4200 kJ) meals in older adults with a CVD risk phenotype. In a randomized crossover study, participants with metabolic syndrome traits (APOE E3, n = 39; E4, n = 10; mean age, 70 & PLUSMN; 5 years; BMI 31.3 & PLUSMN; 3.0 kg/m(2)) consumed a Western-like diet high-fat (WDHF), Western-like diet high-carbohydrate (WDHC), or Mediterranean-like diet (MED) meal. Parameters of lipid and glucose metabolism, inflammatory, and oxidative parameters were analyzed in blood samples collected at fasting and 1-5 h postprandially. Data were analyzed by linear mixed models. The magnitude of the IL-6 increase after the WDHF meal was significantly higher in E4 than in E3 carriers (iAUC: E4 = 7.76 vs. E3 = 2.81 pg/mL x h). The time to detect the IL-6 increase was shorter in the E4 group. All meals produced postprandial glycemia, insulinemia, and lipidemia, without differences between the E3 and the E4 groups. IL-1 beta and oxidized LDL levels did not change postprandially. In conclusion, APOE E4 carriers display increased postprandial inflammation, indicated by higher postprandial IL-6 increase, when compared to non-carriers.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schoenknecht, Yannik Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Crommen, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffel-Wagner, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Coenen, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fimmers, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Stehle, Peter UNSPECIFIED orcid.org/0000-0002-4596-8088 UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Egert, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-592896
DOI:	10.3390/nu13113924
Journal or Publication Title:	Nutrients
Volume:	13
Number:	11
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6643
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language APOLIPOPROTEIN-E GENOTYPE; BLOOD-PRESSURE; DIETARY; RISK; RESPONSIVENESS; MECHANISMS; DISEASE; IMPACT; SEX Multiple languages Nutrition & Dietetics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59289