von Gersdorff, Gero, von Korn, Pia ORCID: 0000-0003-4528-2681, Duvinage, Andre, Ihorst, Gabriele ORCID: 0000-0002-8091-1589, Josef, Anika, Kaufmann, Margit, Baer, Thomas, Fellerhoff, Tim, Fuhrmann, Iris, Koesel, Elisa, Zeissler, Sven, Bobka, Lars, Heinrich, Marion, Schindler, Anette, Weber, Rasmus, Breuer, Cornelia, Meyer, Anna Maria ORCID: 0000-0002-5562-262X, Polidori, M. Cristina, Dinges, Sophia M. T., Schoenfeld, Julia, Siebenbuerger, Mathias, Degenhardt, Stefan, Anding-Rost, Kirsten and Halle, Martin (2021). Cluster Randomized Controlled Trial on the Effects of 12 Months of Combined Exercise Training during Hemodialysis in Patients with Chronic Kidney Disease-Study Protocol of the Dialysis Training Therapy (DiaTT) Trial. Methods Protoc., 4 (3). BASEL: MDPI. ISSN 2409-9279

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Abstract

Patients with chronic kidney disease (CKD) on hemodialysis (HD) experience treatment-related immobility and physical deconditioning, which is responsible for an increased risk of frailty and a high burden of multi-morbidity. Exercise has been shown to counteract this vicious cycle; however, its effectiveness has only been investigated in small cohorts. Therefore, the objective of the Dialysis Training Therapy (DiaTT) trial will be to assess the effects of a 12-month intradialytic exercise program on physical functioning, frailty and health economics in a large cohort of HD patients in a real-world setting. DiaTT will be a prospective, cluster-randomized (1:1), controlled, multi-center, interventional clinical trial across 28 dialysis units, aiming at the recruitment of >1100 CKD patients on HD. The intervention group will receive 12 months' intradialytic exercise (combined aerobic and resistance training), whereas the usual care group will not receive intervention. The primary endpoint will be a change on the sit-to-stand test (STS60) result between baseline and 12 months. Secondary endpoints will include physical functioning, frailty, quality of life, 3-point MACE, hospitalizations, survival, quality of HD, health literacy and health care costs. By including almost as many patients as previously investigated in smaller trials, DiaTT will be the largest randomized, controlled trial assessing frailty, quality of life and mortality in the field of nephrology.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
von Gersdorff, GeroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Korn, PiaUNSPECIFIEDorcid.org/0000-0003-4528-2681UNSPECIFIED
Duvinage, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ihorst, GabrieleUNSPECIFIEDorcid.org/0000-0002-8091-1589UNSPECIFIED
Josef, AnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaufmann, MargitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baer, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fellerhoff, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuhrmann, IrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koesel, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeissler, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bobka, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinrich, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schindler, AnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, RasmusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breuer, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, Anna MariaUNSPECIFIEDorcid.org/0000-0002-5562-262XUNSPECIFIED
Polidori, M. CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dinges, Sophia M. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoenfeld, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siebenbuerger, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Degenhardt, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anding-Rost, KirstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halle, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-596561
DOI: 10.3390/mps4030060
Journal or Publication Title: Methods Protoc.
Volume: 4
Number: 3
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2409-9279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STAGE RENAL-DISEASE; QUALITY-OF-LIFE; INTRADIALYTIC EXERCISE; PHYSICAL FUNCTION; ADULTS; INTERVENTION; METAANALYSIS; CAPACITY; OUTCOMES; PROGRAMMultiple languages
Biochemical Research MethodsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59656

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