Schmid, Benjamin, Holst, Bjorn, Clausen, Christian, Bahnassawy, Lamiaa, Reinhardt, Peter, Bakker, Margot H. M., Diaz-Guerra, Eva, Vicario, Carlos, Martino-Adami, Pamela, V, Thoenes, Michaela, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Flissbach, Klaus, Grezella, Clara, Bruestle, Oliver, Peitz, Michael, Ebneth, Andreas and Cabrera-Socorro, Alfredo (2021). Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (epsilon 2/epsilon 3/epsilon 4) and knock-out for the study of APOE biology in health and disease. Stem Cell Res., 52. AMSTERDAM: ELSEVIER. ISSN 1876-7753

Full text not available from this repository.

Abstract

APOE genotype is the strongest genetic risk factor for Alzheimer's Disease (AD). The low degree of homology between mouse and human APOE is a concerning issue in preclinical models currently used to study the role of this gene in AD pathophysiology. A key objective of ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project was to generate in vitro models that better recapitulate human APOE biology. We describe a new set of induced pluripotent stem cells (iPSC) lines carrying common APOE variants (epsilon 2,epsilon 3, and epsilon 3/epsilon 4) and a knock-out isogenic to the parental APOE epsilon 4/epsilon 4 line (UKBi011-A).

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schmid, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holst, BjornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clausen, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bahnassawy, LamiaaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinhardt, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bakker, Margot H. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diaz-Guerra, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vicario, CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martino-Adami, Pamela, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thoenes, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Flissbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grezella, ClaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruestle, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peitz, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ebneth, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cabrera-Socorro, AlfredoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-599828
DOI: 10.1016/j.scr.2021.102180
Journal or Publication Title: Stem Cell Res.
Volume: 52
Date: 2021
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1876-7753
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59982

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item