Universität zu Köln

Schmidt, Nele, Todt, Inken, Berg, Daniela, Schlenstedt, Christian, Folkerts, Ann-Kristin, Ophey, Anja ORCID: 0000-0001-5858-7762, Dimenshteyn, Karina, Elben, Saskia, Wojtecki, Lars ORCID: 0000-0002-6205-4405, Liepelt-Scarfone, Inga, Schulte, Claudia, Sulzer, Patricia, Eggers, Carsten, Kalbe, Elke and Witt, Karsten (2021). Memory enhancement by multidomain group cognitive training in patients with Parkinson's disease and mild cognitive impairment: long-term effects of a multicenter randomized controlled trial. J. Neurol., 268 (12). S. 4655 - 4667. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

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Abstract

Background Meta-analyses indicate positive effects of cognitive training (CT) in patients with Parkinson's disease (PD), however, most previous studies had small sample sizes and did not evaluate long-term follow-up. Therefore, a multicenter randomized controlled, single-blinded trial (Train-ParC study) was conducted to examine CT effects in PD patients with mild cognitive impairment (PD-MCI). Immediately after CT, an enhancement of executive functions was demonstrated. Here, we present the long-term results 6 and 12 months after CT. Methods At baseline, 64 PD-MCI patients were randomized to a multidomain CT group (n = 33) or to a low-intensity physical activity training control group (PT) (n = 31). Both interventions included 90 min training sessions twice a week for 6 weeks. 54 patients completed the 6 months (CT: n = 28, PT: n = 26) and 49 patients the 12 months follow-up assessment (CT: n = 25, PT: n = 24). Primary study outcomes were memory and executive functioning composite scores. Mixed repeated measures ANOVAs, post-hoc t tests and multiple regression analyses were conducted. Results We found a significant time x group interaction effect for the memory composite score (p = 0.006, eta(2) = 0.214), but not for the executive composite score (p = 0.967, eta(2) = 0.002). Post-hoc t tests revealed significant verbal and nonverbal memory improvements from pre-intervention to 6 months, but not to 12 months follow-up assessment in the CT group. No significant predictors were found for predicting memory improvement after CT. Conclusions This study provides Class 1 evidence that multidomain CT enhances memory functioning in PD-MCI after 6 months but not after 12 months, whereas executive functioning did not change in the long-term.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Nele UNSPECIFIED UNSPECIFIED UNSPECIFIED Todt, Inken UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlenstedt, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Folkerts, Ann-Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ophey, Anja UNSPECIFIED orcid.org/0000-0001-5858-7762 UNSPECIFIED Dimenshteyn, Karina UNSPECIFIED UNSPECIFIED UNSPECIFIED Elben, Saskia UNSPECIFIED UNSPECIFIED UNSPECIFIED Wojtecki, Lars UNSPECIFIED orcid.org/0000-0002-6205-4405 UNSPECIFIED Liepelt-Scarfone, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulte, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Sulzer, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Witt, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-599859
DOI:	10.1007/s00415-021-10568-9
Journal or Publication Title:	J. Neurol.
Volume:	268
Number:	12
Page Range:	S. 4655 - 4667
Date:	2021
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1459
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIAGNOSTIC-CRITERIA; VERBAL MEMORY; OLDER-ADULTS; DEMENTIA; IMPACT; QUESTIONNAIRE; EFFICACY; SYSTEM; RECALL Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59985