Universität zu Köln

Pierling, Anna L., Elmenhorst, Eva-Maria ORCID: 0000-0003-0336-6705, Lange, Denise, Hennecke, Eva, Baur, Diego M., Beer, Simone, Kroll, Tina, Neumaier, Bernd, Aeschbach, Daniel, Bauer, Andreas, Landolt, Hans-Peter and Elmenhorst, David (2021). Cerebral A(1) adenosine receptor availability in female and male participants and its relationship to sleep. Neuroimage, 245. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

The neuromodulator adenosine and its receptors are mediators of sleep-wake regulation which is known to differ between sexes. We, therefore, investigated sex differences in A(1) adenosine receptor (A(1)AR) availability in healthy human subjects under well-rested conditions using [F-18]CPFPX and positron emission tomography (PET). [F-18]CPFPX PET scans were acquired in 50 healthy human participants (20 females; mean age +/- SD 28.0 +/- 5.3 years). Mean binding potential (BPND ; Logan's reference tissue model with cerebellum as reference region) and volume of distribution (V-T) values were calculated in 12 and 15 grey matter brain regions, respectively. [F-18]CPFPX BPND was higher in females compared to males in all investigated brain regions (p < 0.025). The largest differences were found in the pallidum and anterior cingulate cortex, where mean BPND values were higher by 29% in females than in males. In females, sleep efficiency correlated positively and sleep latency negatively with BP ND in most brain regions. V-T values did not differ between sexes. Sleep efficiency correlated positively with V-T in most brain regions in female participants. In conclusion, our analysis gives a first indication for potential sex differences in A(1)AR availability even under well-rested conditions. A(1)AR availability as measured by [F-18]CPFPX BPND is higher in females compared to males. Considering the involvement of adenosine in sleep-wake control, this finding might partially explain the known sex differences in sleep efficiency and sleep latency.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pierling, Anna L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elmenhorst, Eva-Maria UNSPECIFIED orcid.org/0000-0003-0336-6705 UNSPECIFIED Lange, Denise UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennecke, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Baur, Diego M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beer, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroll, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Aeschbach, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Landolt, Hans-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Elmenhorst, David UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-600438
DOI:	10.1016/j.neuroimage.2021.118695
Journal or Publication Title:	Neuroimage
Volume:	245
Date:	2021
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SEX-DIFFERENCES; HUMAN-BRAIN; YOUNG-ADULTS; DOPAMINE; BINDING; DENSITY; AGE; QUANTIFICATION; POLYMORPHISMS; ASSOCIATION Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60043