Universität zu Köln

Hoehfeld, Jorg, Benzing, Thomas, Bloch, Wilhelm, Fuerst, Dieter O., Gehlert, Sebastian ORCID: 0000-0001-6940-3084, Hesse, Michael, Hoffmann, Bernd ORCID: 0000-0002-3803-8835, Hoppe, Thorsten, Huesgen, Pitter F., Koehn, Maja, Kolanus, Waldemar, Merkel, Rudolf, Niessen, Carien M. ORCID: 0000-0002-4892-9391, Pokrzywa, Wojciech ORCID: 0000-0002-5110-4462, Rinschen, Markus M., Wachten, Dagmar and Warscheid, Bettina (2021). Maintaining proteostasis under mechanical stress. EMBO Rep., 22 (8). HOBOKEN: WILEY. ISSN 1469-3178

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Abstract

Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force-unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoehfeld, Jorg UNSPECIFIED UNSPECIFIED UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuerst, Dieter O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gehlert, Sebastian UNSPECIFIED orcid.org/0000-0001-6940-3084 UNSPECIFIED Hesse, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Bernd UNSPECIFIED orcid.org/0000-0002-3803-8835 UNSPECIFIED Hoppe, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Huesgen, Pitter F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehn, Maja UNSPECIFIED UNSPECIFIED UNSPECIFIED Kolanus, Waldemar UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkel, Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Niessen, Carien M. UNSPECIFIED orcid.org/0000-0002-4892-9391 UNSPECIFIED Pokrzywa, Wojciech UNSPECIFIED orcid.org/0000-0002-5110-4462 UNSPECIFIED Rinschen, Markus M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wachten, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Warscheid, Bettina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601056
DOI:	10.15252/embr.202152507
Journal or Publication Title:	EMBO Rep.
Volume:	22
Number:	8
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1469-3178
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROTEIN-QUALITY CONTROL; SKELETAL-MUSCLE HYPERTROPHY; SRC FAMILY KINASE; MOLECULAR CHAPERONE; SLIT DIAPHRAGM; Z-DISC; PHOSPHOPEPTIDE ENRICHMENT; PHOSPHOPROTEOMIC ANALYSIS; CAENORHABDITIS-ELEGANS; CONFORMATIONAL SWITCH Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60105