Salokangas, R. K. R., Hietala, J., Armio, R. L., Laurikainen, H., From, T., Borgwardt, S., Riecher-Rossler, A., Brambilla, P., Bonivento, C., Meisenzahl, E., Schultze-Lutter, F., Haidl, T., Ruhrmann, S., Upthegrove, R., Wood, S. J., Pantelis, C., Kambeitz-Ilankovic, L., Ruef, A., Dwyer, D. B., Kambeitz, J. and Koutsouleris, N. (2021). Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects. Schizophr. Res., 227. S. 101 - 110. AMSTERDAM: ELSEVIER. ISSN 1573-2509

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Abstract

Background: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. Aim: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. Method: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression. Results: Of the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction. Conclusions: Childhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe. (C) 2020 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Salokangas, R. K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hietala, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Armio, R. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laurikainen, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
From, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riecher-Rossler, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brambilla, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonivento, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meisenzahl, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultze-Lutter, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haidl, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Upthegrove, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wood, S. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelis, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz-Ilankovic, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruef, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dwyer, D. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koutsouleris, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-601338
DOI: 10.1016/j.schres.2020.05.041
Journal or Publication Title: Schizophr. Res.
Volume: 227
Page Range: S. 101 - 110
Date: 2021
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1573-2509
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60133

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