Universität zu Köln

Frye, Bjorn C., Gaede, Karoline I., Saltini, Cesare, Rossman, Milton D., Monos, Dimitri S., Rosenman, Ken D., Schuler, Christine R., Weston, Ainsley, Wegner, Ralf, Noth, Rainer, Zissel, Gernot, Schreiber, Stefan, Nothnagel, Michael and Mueller-Quernheim, Joachim (2021). Analysis of single nucleotide polymorphisms in chronic beryllium disease. Respir. Res., 22 (1). LONDON: BMC. ISSN 1465-993X

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Abstract

Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts of beryllium-exposed persons was analysed, no statistically relevant association between any SNP and CBD could be verified. Notably, some SNPs exhibit inverse OR for beryllium sensitization and CBD with nominally statistical significance, which allows hypothesizing about pathophysiological role of genes for the disease triggering and development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Frye, Bjorn C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaede, Karoline I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saltini, Cesare UNSPECIFIED UNSPECIFIED UNSPECIFIED Rossman, Milton D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Monos, Dimitri S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenman, Ken D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuler, Christine R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weston, Ainsley UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegner, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Noth, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Zissel, Gernot UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreiber, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Nothnagel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller-Quernheim, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601573
DOI:	10.1186/s12931-021-01691-2
Journal or Publication Title:	Respir. Res.
Volume:	22
Number:	1
Date:	2021
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1465-993X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SARCOIDOSIS; SUSCEPTIBILITY; ASSOCIATION; ANXA11 Multiple languages Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60157