Wimo, Anders, Belger, Mark, Bon, Jaka, Jessen, Frank, Dumas, Annette, Kramberger, Milica G., Jamilis, Laura, Johansson, Gunilla, Rodrigo Salas, Adrian, Gomez, Octavio Rodriguez, Sannemann, Lena, Stoekenbroek, Malou, Gurruchaga Telleria, Miren, Valero, Sergi, Vermunt, Lisa ORCID: 0000-0001-7420-6384, Waterink, Lisa, Winblad, Bengt, Jelle Visser, Peter, Zwan, Marissa and Boada, Merce (2021). A Cost-Consequence Analysis of Different Screening Procedures in Alzheimer's Disease: Results from the MOPEAD Project. J. Alzheimers Dis., 83 (3). S. 1149 - 1160. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: For care planning and support, under-detection and late diagnosis of Alzheimer's disease (AD) is a great challenge. Models of Patient-Engagement for Alzheimer's Disease (MOPEAD) is an EU-funded project aiming at testing different strategies to improve this situation. Objective: To make a cost-consequence analysis of MOPEAD. Methods: Four screening strategies were tested in five countries (Germany, the Netherlands, Slovenia, Spain, and Sweden): 1) a web-approach; 2) Open-House initiative; 3) in primary care; and 4) by diabetes specialists. Persons-at-risk of AD in all strategies were offered referral to a hospital-based specialist. The primary health-economic outcome was the cost per true-positive case (TP) of AD from the screened population. Results: Of 2,847 screened persons, 1,121 screened positive (39%), 402 were evaluated at memory clinics (14%), and 236 got an AD diagnosis (8%). The cost per TP of those screened was (sic)3,115 with the web-approach, (sic)2,722 with the Open-House, (sic)1,530 in primary care, and (sic)1,190 by diabetes specialists. Sensitivity analyses that more likely reflect the real-world situation confirmed the results. The number-needed-to-screen was 30 with the web-approach, 8 with the Open-House and primary care, and 6 with the diabetes specialists. There were country differences in terms of screening rates, referrals to memory clinics, staff-types involved, and costs per TP. Conclusion: In primary care and by the diabetes specialist, the costs per TP/screened population were lowest, but the capacity of such settings to identify cases with AD-risk must be discussed. Hence new diagnostic strategies such as web-solutions and Open-House initiatives may be valuable after modifications.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wimo, AndersUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Belger, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bon, JakaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dumas, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kramberger, Milica G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jamilis, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johansson, GunillaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodrigo Salas, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomez, Octavio RodriguezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sannemann, LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoekenbroek, MalouUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gurruchaga Telleria, MirenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valero, SergiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vermunt, LisaUNSPECIFIEDorcid.org/0000-0001-7420-6384UNSPECIFIED
Waterink, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winblad, BengtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jelle Visser, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zwan, MarissaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boada, MerceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-602237
DOI: 10.3233/JAD-210303
Journal or Publication Title: J. Alzheimers Dis.
Volume: 83
Number: 3
Page Range: S. 1149 - 1160
Date: 2021
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1875-8908
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEMENTIA; CARE; PEOPLEMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60223

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