Baldermann, Juan Carlos, Schueller, Thomas, Kohl, Sina, Voon, Valerie, Li, Ningfei ORCID: 0000-0003-3315-3591, Hollunder, Barbara ORCID: 0000-0003-0104-6927, Figee, Martijn ORCID: 0000-0003-3679-284X, Haber, Suzanne N., Sheth, Sameer A., Mosley, Philip E., Huys, Daniel ORCID: 0000-0002-9124-4128, Johnson, Kara A., Butson, Christopher, Ackermans, Linda, Vlis, Tim Bouwens van der, Leentjens, Albert F. G., Barbe, Michael, Visser-Vandewalle, Veerle, Kuhn, Jens and Horn, Andreas ORCID: 0000-0002-0695-6025 (2021). Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder. Biol. Psychiatry, 90 (10). S. 678 - 689. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-2402

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Abstract

Obsessive-compulsive disorder is among the most disabling psychiatric disorders. Although deep brain stimulation is considered an effective treatment, its use in clinical practice is not fully established. This is, at least in part, due to ambiguity about the best suited target and insufficient knowledge about underlying mechanisms. Recent advances suggest that changes in broader brain networks are responsible for improvement of obsessions and compulsions, rather than local impact at the stimulation site. These findings were fueled by innovative methodological approaches using brain connectivity analyses in combination with neuromodulatory interventions. Such a connectomic approach for neuromodulation constitutes an integrative account that aims to characterize optimal target networks. In this critical review, we integrate findings from connectomic studies and deep brain stimulation interventions to characterize a neural network presumably effective in reducing obsessions and compulsions. To this end, we scrutinize methodologies and seemingly conflicting findings with the aim to merge observations to identify common and diverse pathways for treating obsessive-compulsive disorder. Ultimately, we propose a unified network that-when modulated by means of cortical or subcortical interventions-alleviates obsessive-compulsive symptoms. https://doi.org/10.1016/j.biopsych.2021.07.010

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Baldermann, Juan CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schueller, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohl, SinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Voon, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, NingfeiUNSPECIFIEDorcid.org/0000-0003-3315-3591UNSPECIFIED
Hollunder, BarbaraUNSPECIFIEDorcid.org/0000-0003-0104-6927UNSPECIFIED
Figee, MartijnUNSPECIFIEDorcid.org/0000-0003-3679-284XUNSPECIFIED
Haber, Suzanne N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sheth, Sameer A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mosley, Philip E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huys, DanielUNSPECIFIEDorcid.org/0000-0002-9124-4128UNSPECIFIED
Johnson, Kara A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Butson, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ackermans, LindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vlis, Tim Bouwens van derUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leentjens, Albert F. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhn, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, AndreasUNSPECIFIEDorcid.org/0000-0002-0695-6025UNSPECIFIED
URN: urn:nbn:de:hbz:38-603542
DOI: 10.1016/j.biopsych.2021.07.010
Journal or Publication Title: Biol. Psychiatry
Volume: 90
Number: 10
Page Range: S. 678 - 689
Date: 2021
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1873-2402
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TERM-FOLLOW-UP; TRANSCRANIAL MAGNETIC STIMULATION; STEREOTACTIC ANTERIOR CAPSULOTOMY; SUBTHALAMIC NUCLEUS; ELECTRICAL-STIMULATION; CINGULATE CORTEX; DOUBLE-BLIND; LONG; CINGULOTOMY; ACCUMBENSMultiple languages
Neurosciences; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60354

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