Yeo, Leonard Leong-Litt, Chen, Vanessa Hui En, Leow, Aloysius Sheng-Ting, Meyer, Lukas ORCID: 0000-0002-3776-638X, Fiehler, Jens, Tu, Tian-Ming, Tham, Carol Huilian, Sia, Ching-Hui, Jamous, Ala ORCID: 0000-0002-8890-2150, Behme, Daniel, Kastrup, Andreas, Papanagiotou, Panagiotis, Styczen, Hanna, Forsting, Michael, Lee, Tsong-Hai, Chu, Chan-Lin, Fischer, Sebastian, Maus, Volker, Abdullayev, Nuran ORCID: 0000-0003-4522-537X, Kabbasch, Christoph, Moench, Sebastian, Maegerlein, Christian, Arnberg, Fabian, Andersson, Tommy, Holmin, Staffan, Teoh, Hock-Luen, Paliwal, Prakash, Ahmad, Aftab, Gopinathan, Anil, Yang, Cunli, Seet, Raymond Chee-Seong, Chan, Bernard Poon-Lap, Sharma, Vijay K. and Tan, Benjamin Yong-Qiang (2021). Outcomes in young adults with acute ischemic stroke undergoing endovascular thrombectomy: A real-world multicenter experience. Eur. J. Neurol., 28 (8). S. 2736 - 2745. HOBOKEN: WILEY. ISSN 1468-1331

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Abstract

Endovascular thrombectomy (EVT) is the standard of care for anterior circulation acute ischemic stroke (AIS) with large vessel occlusion (LVO). Young patients with AIS-LVO have distinctly different underlying stroke mechanisms and etiologies. Much is unknown about the safety and efficacy of EVT in this population of young AIS-LVO patients. All consecutive AIS-LVO patients aged 50 years and below were included in this multicenter cohort study. The primary outcome measured was functional recovery at 90 days, with modified Rankin Scale of 0-2 deemed as good functional outcome. A total of 275 AIS-LVO patients that underwent EVT from 10 tertiary centers in Germany, Sweden, Singapore, and Taiwan were included. Successful reperfusion was achieved in 85.1% (234/275). Good functional outcomes were achieved in 66.0% (182/275). Arterial dissection was the most prevalent stroke etiology (42/195, 21.5%). National Institutes of Health Stroke Scale (NIHSS) score at presentation was inversely related to good functional outcomes (aOR: 0.92, 95% CI: 0.88-0.96 per point increase, p < 0.001). Successful reperfusion (aOR: 3.22, 95% CI: 1.44-7.21, p = 0.005), higher ASPECTS (aOR: 1.21, 95% CI: 1.01-1.44, p = 0.036), and bridging intravenous thrombolysis (aOR: 2.37, 95% CI: 1.29-4.34, p = 0.005) independently predicted good functional outcomes. Successful reperfusion was inversely associated with in-hospital mortality (aOR: 0.14, 95% CI: 0.03-0.57, p = 0.006). History of hypertension strongly predicted in-hospital mortality (aOR: 4.59, 95% CI: 1.10-19.13, p = 0.036). While differences in functional outcomes exist across varying stroke aetiologies, high rates of successful reperfusion and good outcomes are generally achieved in young AIS-LVO patients undergoing EVT.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Yeo, Leonard Leong-LittUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, Vanessa Hui EnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leow, Aloysius Sheng-TingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, LukasUNSPECIFIEDorcid.org/0000-0002-3776-638XUNSPECIFIED
Fiehler, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tu, Tian-MingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tham, Carol HuilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sia, Ching-HuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jamous, AlaUNSPECIFIEDorcid.org/0000-0002-8890-2150UNSPECIFIED
Behme, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kastrup, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papanagiotou, PanagiotisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Styczen, HannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Forsting, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Tsong-HaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chu, Chan-LinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maus, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abdullayev, NuranUNSPECIFIEDorcid.org/0000-0003-4522-537XUNSPECIFIED
Kabbasch, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moench, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maegerlein, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arnberg, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andersson, TommyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holmin, StaffanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teoh, Hock-LuenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paliwal, PrakashUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahmad, AftabUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gopinathan, AnilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, CunliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seet, Raymond Chee-SeongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chan, Bernard Poon-LapUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sharma, Vijay K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, Benjamin Yong-QiangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-603834
DOI: 10.1111/ene.14899
Journal or Publication Title: Eur. J. Neurol.
Volume: 28
Number: 8
Page Range: S. 2736 - 2745
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1468-1331
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEMORRHAGIC TRANSFORMATION; MECHANICAL THROMBECTOMY; INTRAVENOUS ALTEPLASE; THERAPY; TRIAL; EPIDEMIOLOGY; ASSOCIATION; PREDICTORS; MANAGEMENT; RISKMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60383

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