Universität zu Köln

Lillig, Robert, Ophey, Anja ORCID: 0000-0001-5858-7762, Schulz, Joerg B., Reetz, Kathrin ORCID: 0000-0002-9730-9228, Wojtala, Jennifer, Storch, Alexander, Liepelt-Scarfone, Inga, Becker, Sara ORCID: 0000-0002-4595-580X, Berg, Daniela, Balzer-Geldsetzer, Monika, Kassubek, Jan ORCID: 0000-0002-7106-9270, Hilker-Roggendorf, Ruediger, Witt, Karsten, Mollenhauer, Brit, Trenkwalder, Claudia, Roeske, Sandra, Wittchen, Hans-Ullrich, Riedel, Oliver, Dodel, Richard and Kalbe, Elke (2021). A new CERAD total score with equally weighted z-scores and additional executive and non-amnestic CERAD-Plus tests enhances cognitive diagnosis in patients with Parkinson's disease: Evidence from the LANDSCAPE study. Parkinsonism Relat. Disord., 90. S. 90 - 98. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Introduction: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) is a renowned cognitive test battery, which has been extended in its German version to the CERAD-Plus including tests of executive functions and processing speed. The most commonly used total score (TS) is based on the restricted CERAD version and reflects the sum of selected raw-values (Chandler et al., 2005). The CERAD-Plus extensions might be of particular diagnostic utility for cognitive assessments in Parkinson's Disease (PD), as executive functions and processing speed belong to the most vulnerable domains in PD. Objective: The aim was to develop a CERAD-TS based on the extended CERAD-Plus' age-, gender-, and education-corrected z-scores and to evaluate its diagnostic accuracy compared to the established CERAD-Chandler-TS. Methods: Baseline data of n = 679 patients with PD (69% male, n = 277 PD without cognitive impairment, n = 307 PD-MCI, n = 95 PD-D) from the multicenter, prospective DEMPARK/LANDSCAPE study were analyzed. ROC-analyses were conducted for four different TS that were either based on the original CERAD or CERAD-Plus, on raw-values or z-scores, and equally-weighted or based on factor scores. AUC-comparisons were conducted to determine the best yet most parsimonious TS. Results: The newly designed CERAD-Plus-TS based on equally-weighted z-scores outperformed both the CERADChandler-TS and cognitive screening instruments when differentiating between individuals with PD of varying cognitive impairment (0.78 <= AUC <= 0.98). Conclusion: Results suggest a high relevance of non-amnestic subscales for the cognitive assessment in PD populations. The proposed CERAD-Plus-TS needs further validation. The extensions might offer diagnostic potential for non-PD populations as well.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lillig, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Ophey, Anja UNSPECIFIED orcid.org/0000-0001-5858-7762 UNSPECIFIED Schulz, Joerg B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reetz, Kathrin UNSPECIFIED orcid.org/0000-0002-9730-9228 UNSPECIFIED Wojtala, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Storch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepelt-Scarfone, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Sara UNSPECIFIED orcid.org/0000-0002-4595-580X UNSPECIFIED Berg, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Balzer-Geldsetzer, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, Jan UNSPECIFIED orcid.org/0000-0002-7106-9270 UNSPECIFIED Hilker-Roggendorf, Ruediger UNSPECIFIED UNSPECIFIED UNSPECIFIED Witt, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Mollenhauer, Brit UNSPECIFIED UNSPECIFIED UNSPECIFIED Trenkwalder, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Roeske, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittchen, Hans-Ullrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Dodel, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-604037
DOI:	10.1016/j.parkreldis.2021.07.034
Journal or Publication Title:	Parkinsonism Relat. Disord.
Volume:	90
Page Range:	S. 90 - 98
Date:	2021
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1873-5126
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUROPSYCHOLOGICAL ASSESSMENT BATTERY; DEMENTIA ASSESSMENT PANDA; ALZHEIMERS-DISEASE; IMPAIRMENT; ACCURACY Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60403