Salmanton-Garcia, Jon, Sprute, Rosanne ORCID: 0000-0003-2457-6437, Stemler, Jannik, Bartoletti, Michele, Dupont, Damien, Valerio, Maricela, Garcia-Vidal, Carolina, Falces-Romero, Iker, Machado, Marina ORCID: 0000-0002-8370-2248, de la Villa, Sofia ORCID: 0000-0002-1371-6417, Schroeder, Maria, Hoyo, Irma, Hanses, Frank ORCID: 0000-0002-0007-8014, Ferreira-Paim, Kennio ORCID: 0000-0002-6035-8392, Giacobbe, Daniele Roberto ORCID: 0000-0003-2385-1759, Meis, Jacques F., Gangneux, Jean-Pierre, Rodriguez-Guardado, Azucena, Antinori, Spinello, Sal, Ertan ORCID: 0000-0003-2761-2675, Malaj, Xhorxha, Seidel, Danila, Cornely, Oliver A. and Koehler, Philipp ORCID: 0000-0002-7386-7495 (2021). COVID-19-Associated Pulmonary Aspergillosis, March-August 2020. Emerg. Infect. Dis, 27 (4). S. 1077 - 1087. ATLANTA: CENTERS DISEASE CONTROL & PREVENTION. ISSN 1080-6059

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Abstract

Pneumonia caused by severe acute respiratory syndrome coronavirus 2 emerged in China at the end of 2019. Because of the severe immunomodulation and lymphocyte depletion caused by this virus and the subsequent administration of drugs directed at the immune system, we anticipated that patients might experience fungal superinfection. We collected data from 186 patients who had coronavirus disease-associated pulmonary aspergillosis (CAPA) worldwide during March-August 2020. Overall, 182 patients were admitted to the intensive care unit (ICU), including 180 with acute respiratory distress syndrome and 175 who received mechanical ventilation. CAPA was diagnosed a median of 10 days after coronavirus disease diagnosis. Aspergillus fumigatus was identified in 80.3% of patient cultures, 4 of which were azole-resistant. Most (52.7%) patients received voriconazole. In total, 52.2% of patients died; of the deaths, 33.0% were attributed to CAPA. We found that the cumulative incidence of CAPA in the ICU ranged from 1.0% to 39.1%.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Salmanton-Garcia, JonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sprute, RosanneUNSPECIFIEDorcid.org/0000-0003-2457-6437UNSPECIFIED
Stemler, JannikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartoletti, MicheleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dupont, DamienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valerio, MaricelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Vidal, CarolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falces-Romero, IkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Machado, MarinaUNSPECIFIEDorcid.org/0000-0002-8370-2248UNSPECIFIED
de la Villa, SofiaUNSPECIFIEDorcid.org/0000-0002-1371-6417UNSPECIFIED
Schroeder, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoyo, IrmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanses, FrankUNSPECIFIEDorcid.org/0000-0002-0007-8014UNSPECIFIED
Ferreira-Paim, KennioUNSPECIFIEDorcid.org/0000-0002-6035-8392UNSPECIFIED
Giacobbe, Daniele RobertoUNSPECIFIEDorcid.org/0000-0003-2385-1759UNSPECIFIED
Meis, Jacques F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gangneux, Jean-PierreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez-Guardado, AzucenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antinori, SpinelloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sal, ErtanUNSPECIFIEDorcid.org/0000-0003-2761-2675UNSPECIFIED
Malaj, XhorxhaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidel, DanilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, PhilippUNSPECIFIEDorcid.org/0000-0002-7386-7495UNSPECIFIED
URN: urn:nbn:de:hbz:38-605244
DOI: 10.3201/eid2704.204895
Journal or Publication Title: Emerg. Infect. Dis
Volume: 27
Number: 4
Page Range: S. 1077 - 1087
Date: 2021
Publisher: CENTERS DISEASE CONTROL & PREVENTION
Place of Publication: ATLANTA
ISSN: 1080-6059
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INVASIVE ASPERGILLOSIS; CORONAVIRUS DISEASE; COVID-19Multiple languages
Immunology; Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60524

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