Gill, Christian M., Aktas, Elif, Alfouzan, Wadha, Bourassa, Lori ORCID: 0000-0001-8903-5274, Brink, Adrian, Burnham, Carey-Ann D., Canton, Rafael ORCID: 0000-0003-1675-3173, Carmeli, Yehuda, Falcone, Marco, Kiffer, Carlos, Marchese, Anna ORCID: 0000-0002-3188-3518, Martinez, Octavio, Pournaras, Spyros, Seifert, Harald, Thabit, Abrar K., Virginia Villegas, Maria, Westblade, Lars F. and Nicolau, David P. (2021). Elevated MICs of Susceptible Antipseudomonal Cephalosporins in Non-Carbapenemase-Producing, Carbapenem-Resistant Pseudomonas aeruginosa: Implications for Dose Optimization. Antimicrob. Agents Chemother., 65 (11). WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 1098-6596

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Abstract

YThe present study evaluated the in vitro potency of ceftazidime and cefepime among carbapenem-resistant Pseudomonas aeruginosa isolates collected as part of a global surveillance program and assessed the pharmacodynamic implications using previously published population pharmacokinetics. When susceptible, MICs resulted at the high end of distribution for both ceftazidime and cefepime, thus 6 g/day was required to achieve optimal pharmacodynamic profiles. These findings should be considered in the clinic and for the application of CLSI susceptibility breakpoints.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gill, Christian M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aktas, ElifUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alfouzan, WadhaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bourassa, LoriUNSPECIFIEDorcid.org/0000-0001-8903-5274UNSPECIFIED
Brink, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burnham, Carey-Ann D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canton, RafaelUNSPECIFIEDorcid.org/0000-0003-1675-3173UNSPECIFIED
Carmeli, YehudaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falcone, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiffer, CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchese, AnnaUNSPECIFIEDorcid.org/0000-0002-3188-3518UNSPECIFIED
Martinez, OctavioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pournaras, SpyrosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thabit, Abrar K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Virginia Villegas, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westblade, Lars F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nicolau, David P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605771
DOI: 10.1128/AAC.01204-21
Journal or Publication Title: Antimicrob. Agents Chemother.
Volume: 65
Number: 11
Date: 2021
Publisher: AMER SOC MICROBIOLOGY
Place of Publication: WASHINGTON
ISSN: 1098-6596
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CEFEPIME; PHARMACODYNAMICSMultiple languages
Microbiology; Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60577

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