Quhal, Fahad ORCID: 0000-0002-8163-6953, Rajwa, Pawel, Mori, Keiic, Laukhtina, Ekaterina, Grossmann, Nico, Schuettfort, Victor M., Koenig, Frederik, Aydh, Abdulmajeed, Motlagh, Reza S., Katayama, Satoshi, Mostafai, Hadi, Pradere, Benjamin, Marra, Giancarlo, Gontero, Paolo, Mathieu, Romain, Karakiewicz, Pierre I., Briganti, Alberto, Shariat, Shahrokh F. and Heidenreich, Axel (2021). The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer. Prostate, 81 (11). S. 765 - 772. HOBOKEN: WILEY. ISSN 1097-0045

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Abstract

Purpose To examine the effect of lymph node dissection on the outcomes of patients who underwent salvage radical prostatectomy (SRP). Material and Methods We retrospectively reviewed data from radiation-recurrent patients with prostate cancer (PCa) who underwent SRP from 2000-2016. None of the patients had clinical lymph node involvement before SRP. The effect of the number of removed lymph nodes (RLNs) and the number of positive lymph nodes (PLNs) on biochemical recurrence (BCR)-free survival, metastases free survival, and overall survival (OS) was tested in multivariable Cox regression analyses. Results About 334 patients underwent SRP and pelvic lymph node dissection (PLND). Lymph node involvement was associated with increased risk of BCR (p < .001), metastasis (p < .001), and overall mortality (p = .006). In a multivariable Cox regression analysis, an increased number of RLNs significantly lowered the risk of BCR (hazard ratio [HR] 0.96, p = .01). In patients with positive lymph nodes, a higher number of RLNs and a lower number of PLNs were associated with improved freedom from BCR (HR 0.89, p = .001 and HR 1.34, p = .008, respectively). At a median follow-up of 23.9 months (interquartile range, 4.7-37.7), neither the number of RLNs nor the number of PLNs were associated with OS (p = .69 and p = .34, respectively). Conclusion Pathologic lymph node involvement increased the risk of BCR, metastasis and overall mortality in radiation-recurrent PCa patients undergoing SRP. The risk of BCR decreased steadily with a higher number of RLNs during SRP. Further research is needed to support this conclusion and develop a precise therapeutic adjuvant strategy based on the number of RLNs and PLNs.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Quhal, FahadUNSPECIFIEDorcid.org/0000-0002-8163-6953UNSPECIFIED
Rajwa, PawelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mori, KeiicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laukhtina, EkaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grossmann, NicoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuettfort, Victor M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, FrederikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aydh, AbdulmajeedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Motlagh, Reza S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katayama, SatoshiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mostafai, HadiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pradere, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marra, GiancarloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gontero, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mathieu, RomainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karakiewicz, Pierre I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Briganti, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shariat, Shahrokh F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heidenreich, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605823
DOI: 10.1002/pros.24173
Journal or Publication Title: Prostate
Volume: 81
Number: 11
Page Range: S. 765 - 772
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1097-0045
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SURVIVAL; THERAPY; FAILURE; RADIOTHERAPY; MEN; PATTERNS; OUTCOMES; SURGERYMultiple languages
Endocrinology & Metabolism; Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60582

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