Schirmbeck, Frederike ORCID: 0000-0003-1700-0958, van der Burg, Nadine C., Blankers, Matthijs, Vermeulen, Jentien M., McGuire, Philip ORCID: 0000-0003-4381-0532, Valmaggia, Lucia R., Kempton, Matthew J., van der Gaag, Mark, Riecher-Rossler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus ORCID: 0000-0002-8671-1238, Nelson, Barnaby, Amminger, G. Paul, McGorry, Patrick ORCID: 0000-0002-3789-6168, Pantelis, Christos, Krebs, Marie-Odile, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Nordentoft, Merete, Glenthoj, Birte, Fusar-Poli, Paolo ORCID: 0000-0003-3582-6788 and de Haan, Lieuwe (2022). Impact of Comorbid Affective Disorders on Longitudinal Clinical Outcomes in Individuals at Ultra-high Risk for Psychosis. Schizophr. Bull., 48 (1). S. 100 - 111. OXFORD: OXFORD UNIV PRESS. ISSN 1745-1701

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Abstract

Introduction: Diagnoses of anxiety and/or depression are common in subjects at Ultra-High Risk for Psychosis (UHR) and associated with extensive functional impairment. Less is known about the impact of affective comorbidities on the prospective course of attenuated psychotic symptoms (APS). Method: Latent class mixed modelling identified APS trajectories in 331 UHR subjects assessed at baseline, 6, 12, and 24 months follow-up. The prognostic value of past, baseline, and one-year DSM-IV depressive or anxiety disorders on trajectories was investigated using logistic regression, controlling for confounders. Cox proportional hazard analyses investigated associations with transition risk. Results: 46.8% of participants fulfilled the criteria for a past depressive disorder, 33.2% at baseline, and 15.1% at one-year follow-up. Any past, baseline, or one-year anxiety disorder was diagnosed in 42.9%, 37.2%, and 27.0%, respectively. Participants were classified into one of three latent APS trajectory groups: (1) persistently low, (2) increasing, and (3) decreasing. Past depression was associated with a higher risk of belonging to the increasing trajectory group, compared to the persistently low (OR = 3.149, [95%CI: 1.298-7.642]) or decreasing group (OR = 3.137, [1.165-8.450]). In contrast, past (OR =.443, [.179-1.094]) or current (OR =.414, [.156-1.094]) anxiety disorders showed a trend-level association with a lower risk of belonging to the increasing group compared to the persistently low group. Past depression was significantly associated with a higher risk of transitioning to psychosis (HR = 2.123, [1.178-3.828]). Conclusion: A past depressive episode might be a particularly relevant risk factor for an unfavorable course of APS in UHR individuals. Early affective disturbances may be used to advance detection, prognostic, and clinical strategies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schirmbeck, FrederikeUNSPECIFIEDorcid.org/0000-0003-1700-0958UNSPECIFIED
van der Burg, Nadine C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blankers, MatthijsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vermeulen, Jentien M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGuire, PhilipUNSPECIFIEDorcid.org/0000-0003-4381-0532UNSPECIFIED
Valmaggia, Lucia R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kempton, Matthew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Gaag, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riecher-Rossler, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bressan, Rodrigo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrantes-Vidal, NeusUNSPECIFIEDorcid.org/0000-0002-8671-1238UNSPECIFIED
Nelson, BarnabyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amminger, G. PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGorry, PatrickUNSPECIFIEDorcid.org/0000-0002-3789-6168UNSPECIFIED
Pantelis, ChristosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krebs, Marie-OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachs, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rutten, Bart P. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Os, JimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordentoft, MereteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glenthoj, BirteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fusar-Poli, PaoloUNSPECIFIEDorcid.org/0000-0003-3582-6788UNSPECIFIED
de Haan, LieuweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605977
DOI: 10.1093/schbul/sbab088
Journal or Publication Title: Schizophr. Bull.
Volume: 48
Number: 1
Page Range: S. 100 - 111
Date: 2022
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1745-1701
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHILDHOOD TRAUMA; AT-RISK; PERSISTENCE; DEPRESSION; ONSET; YOUTH; STATE; SCHIZOPHRENIA; METAANALYSIS; EXPERIENCESMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60597

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