Schiele, Miriam A., Reif, Andreas, Lin, Jiaxi, Alpers, Georg W. ORCID: 0000-0001-9896-5158, Andersson, Evelyn, Andersson, Gerhard ORCID: 0000-0003-4753-6745, Arolt, Volker, Bergstrom, Jan, Carlbring, Per, Eley, Thalia C., Esquivel, Gabriel, Furmark, Tomas, Gerlach, Alexander L., Hamm, Alfons, Helbig-Lang, Sylvia, Hudson, Jennifer L., Lang, Thomas, Lester, Kathryn J., Lindefors, Nils, Lonsdorf, Tina B., Pauli, Paul, Richter, Jan ORCID: 0000-0002-7127-6990, Rief, Winfried ORCID: 0000-0002-7019-2250, Roberts, Susanna, Rueck, Christian, Schruers, Koen R. J., Thiel, Christiane, Wittchen, Hans-Ulrich ORCID: 0000-0002-6311-7711, Domschke, Katharina, Weber, Heike and Lueken, Ulrike (2021). Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: A meta-analysis. Eur. Neuropsychopharmacol., 44. S. 105 - 121. AMSTERDAM: ELSEVIER. ISSN 1873-7862

Full text not available from this repository.

Abstract

There is a recurring debate on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in the moderation of response to cognitive behavioral therapy (CBT) in anxiety disorders. Results, however, are still inconclusive. We here aim to perform a meta-analysis on the role of 5-HTTLPR in the moderation of CBT outcome in anxiety disorders. We investigated both categorical (symptom reduction of at least 50%) and dimensional outcomes from baseline to post-treatment and follow-up. Original data were obtained from ten independent samples (including three unpublished samples) with a total of 2,195 patients with primary anxiety disorder. No significant effects of 5-HTTLPR genotype on categorical or dimensional outcomes at post and follow-up were detected. We conclude that current evidence does not support the hypothesis of 5-HTTLPR as a moderator of treatment outcome for CBT in anxiety disorders. Future research should address whether other factors such as long-term changes or epigenetic processes may explain further variance in these complex gene-environment interactions and molecular-genetic pathways that may confer behavioral change following psychotherapy. Crown Copyright (C) 2021 Published by Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schiele, Miriam A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reif, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lin, JiaxiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alpers, Georg W.UNSPECIFIEDorcid.org/0000-0001-9896-5158UNSPECIFIED
Andersson, EvelynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andersson, GerhardUNSPECIFIEDorcid.org/0000-0003-4753-6745UNSPECIFIED
Arolt, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergstrom, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carlbring, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eley, Thalia C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esquivel, GabrielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Furmark, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerlach, Alexander L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamm, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Helbig-Lang, SylviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hudson, Jennifer L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lester, Kathryn J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindefors, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lonsdorf, Tina B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pauli, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richter, JanUNSPECIFIEDorcid.org/0000-0002-7127-6990UNSPECIFIED
Rief, WinfriedUNSPECIFIEDorcid.org/0000-0002-7019-2250UNSPECIFIED
Roberts, SusannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueck, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schruers, Koen R. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiel, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittchen, Hans-UlrichUNSPECIFIEDorcid.org/0000-0002-6311-7711UNSPECIFIED
Domschke, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, HeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lueken, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-606056
DOI: 10.1016/j.euroneuro.2021.01.004
Journal or Publication Title: Eur. Neuropsychopharmacol.
Volume: 44
Page Range: S. 105 - 121
Date: 2021
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1873-7862
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SEROTONIN TRANSPORTER GENE; PROMOTER POLYMORPHISM 5-HTTLPR; TREATMENT RESPONSE; PANIC DISORDER; ENVIRONMENT INTERACTION; CHILDHOOD TRAUMA; LIFE EVENTS; ASSOCIATION; DEPRESSION; STRESSMultiple languages
Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60605

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item