Seidel, Christoph ORCID: 0000-0002-6023-6336, Daugaard, Gedske, Nestler, Tim, Tryakin, Alexey, Fedyanin, Mikhail, Fankhauser, Christian Daniel, Hermanns, Thomas, Aparicio, Jorge, Heinzelbecker, Julia, Paffenholz, Pia, Heidenreich, Axel, De Giorgi, Ugo, Cathomas, Richard, Lorch, Anja, Fingerhut, Anna, Gayer, Fabian, Bremmer, Felix, Giannatempo, Patrizia, Necchi, Andrea, Raggi, Daniele ORCID: 0000-0002-4185-2475, Aurilio, Gaetano, Casadei, Chiara, Hentrich, Marcus, Tran, Ben, Dieckmann, Klaus-Peter, Brito, Margarido, Ruf, Christian, Mazzocca, Alessandro, Vincenzi, Bruno, Stahl, Olof, Bokemeyer, Carsten and Oing, Christoph (2021). The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3). World J. Urol., 39 (9). S. 3407 - 3415. NEW YORK: SPRINGER. ISSN 1433-8726

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Abstract

Purpose The prognostic significance of lactate dehydrogenase (LDH) in patients with metastatic seminoma is not defined. We investigated the prognostic impact of LDH levels prior to first-line systemic treatment and other clinical characteristics in this subset of patients. Methods Files from two registry studies and one single-institution database were analyzed retrospectively. Uni- and multivariate analyses were conducted to identify patient characteristics associated with recurrence free survival (RFS), overall survival (OS), and complete response rate (CRR). Results The dataset included 351 metastatic seminoma patients with a median follow-up of 5.36 years. Five-year RFS, OS and CRR were 82%, 89% and 52%, respectively. Explorative analysis revealed a cut-off LDH level of < 2.5 upper limit of normal (ULN) (n = 228) vs. >= 2.5 ULN (n = 123) to be associated with a significant difference concerning OS associated with 5-years OS rates of 93% vs. 83% (p = 0.001) which was confirmed in multivariate analysis (HR 2.87; p = 0.004). Furthermore, the cut-off LDH < 2.5 ULN vs. >= 2.5 ULN correlated with RFS and CRR associated with a 5-years RFS rate and CRR of 76% vs. 86% (p = 0.012) and 32% vs. 59% (p <= 0.001), respectively. Conclusions LDH levels correlate with treatment response and survival in metastatic seminoma patients and should be considered for their prognostic stratification.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Seidel, ChristophUNSPECIFIEDorcid.org/0000-0002-6023-6336UNSPECIFIED
Daugaard, GedskeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nestler, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tryakin, AlexeyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fedyanin, MikhailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fankhauser, Christian DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermanns, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aparicio, JorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinzelbecker, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paffenholz, PiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heidenreich, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Giorgi, UgoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cathomas, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorch, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fingerhut, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gayer, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bremmer, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giannatempo, PatriziaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Necchi, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raggi, DanieleUNSPECIFIEDorcid.org/0000-0002-4185-2475UNSPECIFIED
Aurilio, GaetanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Casadei, ChiaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hentrich, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tran, BenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dieckmann, Klaus-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brito, MargaridoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruf, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mazzocca, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vincenzi, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stahl, OlofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bokemeyer, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oing, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-606127
DOI: 10.1007/s00345-021-03635-3
Journal or Publication Title: World J. Urol.
Volume: 39
Number: 9
Page Range: S. 3407 - 3415
Date: 2021
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1433-8726
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60612

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