Kliesch, Sabine, Schmidt, Stefanie, Wilborn, Doris, Aigner, Clemens ORCID: 0000-0002-7787-991X, Albrecht, Walter, Bedke, Jens, Beintker, Matthias, Beyersdorff, Dirk, Bokemeyer, Carsten, Busch, Jonas, Classen, Johannes, De Wit, Maike, Dieckmann, Klaus-Peter, Diemer, Thorsten, Dieing, Anette, Gockel, Matthias, Goeckel-Beining, Bernt, Hakenberg, Oliver W., Heidenreich, Axel, Heinzelbecker, Julia, Herkommer, Kathleen, Hermanns, Thomas, Kaufmann, Sascha, Kornmann, Marko, Kotzerke, Joerg, Krege, Susanne, Kristiansen, Glen, Lorch, Anja, Mueller, Arndt-Christian, Oechsle, Karin, Ohloff, Timur, Oing, Christoph, Otto, Ulrich, Pfister, David, Pichler, Renate, Recken, Heinrich, Rick, Oliver, Rudolph, Yvonne, Ruf, Christian, Schirren, Joachim, Schmelz, Hans, Schmidberger, Heinz, Schrader, Mark, Schweyer, Stefan, Seeling, Stefanie, Souchon, Rainer, Winter, Christian, Wittekind, Christian, Zengerling, Friedemann, Zermann, D. H., Zillmann, Roger and Albers, Peter (2021). Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy. Urol.Int., 105 (3-4). S. 181 - 192. BASEL: KARGER. ISSN 1423-0399

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Abstract

Objectives: We developed the first German evidence- and consensus-based clinical guideline on diagnosis, treatment, and follow-up of germ cell tumours (GCT) of the testes in adult patients. We present the guideline content in 2 separate publications. The present second part summarizes therecommendations for the treatment of advanced disease stages and for the management of follow-up and late effects. Materials and Methods: An interdisciplinary panel of 42 experts including 1 patient representative developed the guideline content. Clinical recommendations and statements were based on scientific evidence and expert consensus. For this purpose, evidence tables for several review questions, which were based on systematic literature searches (last search in March 2018), were provided. Thirty-one experts, who were entitled to vote, rated the final clinical recommendations and statements. Results: Here we present the treatment recommendations separately for patients with metastatic seminoma and non-seminomatous GCT (stages IIA/B and IIC/III), for restaging and treatment of residual masses, and for relapsed and refractory disease stages. The recommendations also cover extragonadal and sex cord/stromal tumours, the management of follow-up and toxicity, quality-of-life aspects, palliative care, and supportive therapy. Conclusion: Physicians and other medical service providers who are involved in the diagnostics, treatment, and follow-up of GCT (all stages, outpatient and inpatient care as well as rehabilitation) are the users of the present guideline. The guideline also comprises quality indicators for measuring the implementation of the guideline recommendations in routine clinical care; these data will be presented in a future publication.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kliesch, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilborn, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aigner, ClemensUNSPECIFIEDorcid.org/0000-0002-7787-991XUNSPECIFIED
Albrecht, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bedke, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beintker, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beyersdorff, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bokemeyer, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Busch, JonasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Classen, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Wit, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dieckmann, Klaus-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diemer, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dieing, AnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gockel, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goeckel-Beining, BerntUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hakenberg, Oliver W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heidenreich, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinzelbecker, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herkommer, KathleenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermanns, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaufmann, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornmann, MarkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kotzerke, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krege, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kristiansen, GlenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorch, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, Arndt-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oechsle, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ohloff, TimurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oing, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Otto, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pichler, RenateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Recken, HeinrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rick, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rudolph, YvonneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruf, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schirren, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmelz, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidberger, HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schrader, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schweyer, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seeling, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Souchon, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winter, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittekind, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zengerling, FriedemannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zermann, D. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zillmann, RogerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albers, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-607433
DOI: 10.1159/000511245
Journal or Publication Title: Urol.Int.
Volume: 105
Number: 3-4
Page Range: S. 181 - 192
Date: 2021
Publisher: KARGER
Place of Publication: BASEL
ISSN: 1423-0399
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60743

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