Bruni, Cosimo ORCID: 0000-0003-2813-2083, Buch, Maya H., Furst, Daniel E., De Luca, Giacomo, Djokovic, Aleksandra, Dumitru, Raluca B., Giollo, Alessandro, Polovina, Marija, Steelandt, Alexia, Bratis, Kostantinos, Suliman, Yossra Atef, Milinkovic, Ivan, Baritussio, Anna, Hasan, Ghadeer, Xintarakou, Anastasia, Isomura, Yohei, Markousis-Mavrogenis, George, Tofani, Lorenzo, Mavrogeni, Sophie, Gargani, Luna, Caforio, Alida L. P., Tschoepe, Carsten, Ristic, Arsen, Klingel, Karin, Plein, Sven, Behr, Elijah R., Allanore, Yannick, Kuwana, Masataka, Denton, Christopher P., Khanna, Dinesh, Krieg, Thomas, Marcolongo, Renzo, Galetti, Ilaria, Zanatta, Elisabetta, Tona, Francesco, Seferovic, Petar and Matucci-Cerinic, Marco (2022). Primary systemic sclerosis heart involvement: A systematic literature review and preliminary data-driven, consensus-based WSF/HFA definition. J. Scleroderma Relat. Disord., 7 (1). S. 24 - 33. LONDON: SAGE PUBLICATIONS LTD. ISSN 2397-1991

Full text not available from this repository.

Abstract

Introduction: Primary heart involvement in systemic sclerosis may cause morpho-functional and electrical cardiac abnormalities and is a common cause of death. The absence of a clear definition of primary heart involvement in systemic sclerosis limits our understanding and ability to focus on clinical research. We aimed to create an expert consensus definition for primary heart involvement in systemic sclerosis. Methods: A systematic literature review of cardiac involvement and manifestations in systemic sclerosis was conducted to inform an international and multi-disciplinary task force. In addition, the nominal group technique was used to derive a definition that was then subject to voting. A total of 16 clinical cases were evaluated to test face validity, feasibility, reliability and criterion validity of the newly created definition. Results: In total, 171 publications met eligibility criteria. Using the nominal group technique, experts added their opinion, provided statements to consider and ranked them to create the consensus definition, which received 100% agreement on face validity. A median 60(5-300) seconds was taken for the feasibility on a single case. Inter-rater agreement was moderate (mKappa (95% CI) = 0.56 (0.46-1.00) for the first round and 0.55 (0.44-1.00) for the second round) and intra-rater agreement was good (mKappa (95% CI) = 0.77 (0.47-1.00)). Criterion validity showed a 78 (73-84)% correctness versus gold standard. Conclusion: A preliminary primary heart involvement in systemic sclerosis consensus-based definition was created and partially validated, for use in future clinical research.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bruni, CosimoUNSPECIFIEDorcid.org/0000-0003-2813-2083UNSPECIFIED
Buch, Maya H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Furst, Daniel E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Luca, GiacomoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Djokovic, AleksandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dumitru, Raluca B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giollo, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polovina, MarijaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steelandt, AlexiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bratis, KostantinosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suliman, Yossra AtefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milinkovic, IvanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baritussio, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasan, GhadeerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xintarakou, AnastasiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Isomura, YoheiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Markousis-Mavrogenis, GeorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tofani, LorenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mavrogeni, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gargani, LunaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caforio, Alida L. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tschoepe, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ristic, ArsenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klingel, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plein, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behr, Elijah R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allanore, YannickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuwana, MasatakaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Denton, Christopher P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khanna, DineshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krieg, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marcolongo, RenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galetti, IlariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zanatta, ElisabettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tona, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seferovic, PetarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matucci-Cerinic, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-607520
DOI: 10.1177/23971983211053246
Journal or Publication Title: J. Scleroderma Relat. Disord.
Volume: 7
Number: 1
Page Range: S. 24 - 33
Date: 2022
Publisher: SAGE PUBLICATIONS LTD
Place of Publication: LONDON
ISSN: 2397-1991
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PULMONARY ARTERIAL-HYPERTENSION; DISEASE; PATHOGENESIS; MANAGEMENT; MORTALITYMultiple languages
RheumatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60752

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item