Kliesch, Sabine, Schmidt, Stefanie, Wilborn, Doris, Aigner, Clemens ORCID: 0000-0002-7787-991X, Albrecht, Walter, Bedke, Jens, Beintker, Matthias, Beyersdorff, Dirk, Bokemeyer, Carsten, Busch, Jonas, Classen, Johannes, de Wit, Maike, Dieckmann, Klaus-Peter, Diemer, Thorsten, Dieing, Anette, Gockel, Matthias, Goeckel-Beining, Bernt, Hakenberg, Oliver W., Heidenreich, Axel, Heinzelbecker, Julia, Herkommer, Kathleen, Hermanns, Thomas, Kaufmann, Sascha, Kornmann, Marko, Kotzerke, Jorg, Krege, Susanne, Kristiansen, Glen, Lorch, Anja, Mueller, Arndt-Christian, Oechsle, Karin, Ohloff, Timur, Oing, Christoph, Otto, Ulrich, Pfister, David, Pichler, Renate, Recken, Heinrich, Rick, Oliver, Rudolph, Yvonne, Ruf, Christian, Schirren, Joachim, Schmelz, Hans, Schmidberger, Heinz, Schrader, Mark, Schweyer, Stefan, Seeling, Stefanie, Souchon, Rainer, Winter, Christian, Wittekind, Christian, Zengerling, Friedemann, Zermann, Dirk-Henrik, Zillmann, Roger and Albers, Peter (2021). Management of Germ Cell Tumours of the Testis in Adult Patients. German Clinical Practice Guideline Part I: Epidemiology, Classification, Diagnosis, Prognosis, Fertility Preservation, and Treatment Recommendations for Localized Stages. Urol.Int., 105 (3-4). S. 169 - 181. BASEL: KARGER. ISSN 1423-0399

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Abstract

Introduction: This is the first German evidence- and consensus-based clinical guideline on diagnosis, treatment, and follow-up on germ cell tumours (GCTs) of the testis in adult patients. We present the guideline content in two publications. Part I covers the topic's background, methods, epidemiology, classification systems, diagnostics, prognosis, and treatment recommendations for the localized stages. Methods: An interdisciplinary panel of 42 experts including 1 patient representative developed the guideline content. Clinical recommendations and statements were based on scientific evidence and expert consensus. For this purpose, evidence tables for several review questions, which were based on systematic literature searches (last search was in March 2018) were provided. Thirty-one experts entitled to vote, rated the final clinical recommendations and statements. Results: We provide 161 clinical recommendations and statements. We present information on the quality of cancer care and epidemiology and give recommendations for staging and classification as well as for diagnostic procedures. The diagnostic recommendations encompass measures for assessing the primary tumour as well as procedures for the detection of metastases. One chapter addresses prognostic factors. In part I, we separately present the treatment recommendations for germ cell neoplasia in situ, and the organ-confined stages (clinical stage I) of both seminoma and nonseminoma. Conclusion: Although GCT is a rare tumour entity with excellent survival rates for the localized stages, its management requires an interdisciplinary approach, including several clinical experts. Quality of care is highly related to institutional expertise and can be reassured by established online-based second-opinion boards. There are very few studies on diagnostics with good level of evidence. Treatment of metastatic GCTs must be tailored to the risk according to the International Germ Cell Cancer Collaboration Group classification after careful diagnostic evaluation. An interdisciplinary approach as well as the referral of selected patients to centres with proven experience can help achieve favourable clinical outcomes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kliesch, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilborn, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aigner, ClemensUNSPECIFIEDorcid.org/0000-0002-7787-991XUNSPECIFIED
Albrecht, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bedke, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beintker, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beyersdorff, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bokemeyer, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Busch, JonasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Classen, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Wit, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dieckmann, Klaus-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diemer, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dieing, AnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gockel, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goeckel-Beining, BerntUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hakenberg, Oliver W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heidenreich, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinzelbecker, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herkommer, KathleenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermanns, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaufmann, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornmann, MarkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kotzerke, JorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krege, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kristiansen, GlenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorch, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, Arndt-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oechsle, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ohloff, TimurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oing, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Otto, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pichler, RenateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Recken, HeinrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rick, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rudolph, YvonneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruf, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schirren, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmelz, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidberger, HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schrader, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schweyer, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seeling, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Souchon, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winter, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittekind, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zengerling, FriedemannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zermann, Dirk-HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zillmann, RogerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albers, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-607570
DOI: 10.1159/000510407
Journal or Publication Title: Urol.Int.
Volume: 105
Number: 3-4
Page Range: S. 169 - 181
Date: 2021
Publisher: KARGER
Place of Publication: BASEL
ISSN: 1423-0399
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TERM-FOLLOW-UP; EUROPEAN CONSENSUS CONFERENCE; TESTICULAR CANCER; ADJUVANT CHEMOTHERAPY; GROUP EGCCCG; SURVEILLANCEMultiple languages
Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60757

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