Universität zu Köln

Djordjevic, Ilija ORCID: 0000-0002-5810-8626, Ivanov, Borko, Sabashnikov, Anton, Gaisendrees, Christopher, Gerfer, Stephen ORCID: 0000-0002-6568-6766, Suhr, Laura, Avgeridou, Soi, Merkle-Storms, Julia, Mihaylova, Mariya, Eghbalzadeh, Kaveh, Kuhn, Elmar and Wahlers, Thorsten (2022). Impact of Obesity on In-Hospital Outcomes in Veno-Arterial ECMO Patients. Heart Lung Circ., 31 (10). S. 1393 - 1399. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1444-2892

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Abstract

Background Obesity is known to impact outcomes of patients undergoing in-patient care in general. The association between veno-arterial extracorporeal membrane oxygenation (VA ECMO) and obesity-related outcomes remains unclear. Therefore, we sought to investigate weight-associated differences of patients treated with VA ECMO. Method A retrospective study was performed for patients who required veno-arterial (VA) ECMO support at our tertiary ECMO centre between 1 March 2006 and 28 February 2017. Patients were categorised according to Body-Mass-Index (BMI) associated values in six groups (underweight, normal range, overweight, obese class I-III). Further, patients were divided into non-obese (18.5-29-9 kg/m(2)) and obese (>= 30 kg/m(2)) groups and analysed concerning baseline, ECMO-related, and general outcome parameters. Results A total of 244 patients required VA ECMO support during the study period. Subgroup-analysis of BMI-category associated impact on in-hospital mortality showed the highest incidence of mortality in obese class II patients (93%) with a significant difference between overweighted patients. Non-obesity was present in 179, whereas 59 patients suffered obesity. Obese patients were significantly older (p=0.022) and suffered significantly more diabetes (21% non-obese vs 48% obese; p,0.001). Indication for support, laboratory parameters prior to ECMO, and ECMO-related outcomes did not differ between the groups. Obese patients showed a trend towards higher in-hospital mortality (70% non-obese vs 81% obese; p=0.085). Conclusions Obesity is associated with comparable outcomes to non-obese patients, showing a tendency of higher mortality. Obese class II patients presented the highest risk of death compared to all BMI categories.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Djordjevic, Ilija UNSPECIFIED orcid.org/0000-0002-5810-8626 UNSPECIFIED Ivanov, Borko UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabashnikov, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaisendrees, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerfer, Stephen UNSPECIFIED orcid.org/0000-0002-6568-6766 UNSPECIFIED Suhr, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Avgeridou, Soi UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkle-Storms, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Mihaylova, Mariya UNSPECIFIED UNSPECIFIED UNSPECIFIED Eghbalzadeh, Kaveh UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Elmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-660695
DOI:	10.1016/j.hlc.2022.03.014
Journal or Publication Title:	Heart Lung Circ.
Volume:	31
Number:	10
Page Range:	S. 1393 - 1399
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1444-2892
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRACORPOREAL; CONTRAINDICATION Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66069