Universität zu Köln

Krasivskyi, Ihor ORCID: 0000-0003-0573-8218, Ivanov, Borko, Vehrenberg, Johannes, Eghbalzadeh, Kaveh ORCID: 0000-0001-6941-7785, Gerfer, Stephen, Gaisendrees, Christopher, Kuhn, Elmar, Sabashnikov, Anton, Mader, Navid, Djordjevic, Ilija ORCID: 0000-0002-5810-8626 and Wahlers, Thorsten (2022). Sex-Related Differences in Short-Term Outcomes after Mobile VA-ECMO Implantation: Five-Year Experience of an ECMO Retrieval Program. Life-Basel, 12 (11). BASEL: MDPI. ISSN 2075-1729

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Abstract

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) represents an increasingly used method for circulatory support. Despite the ongoing research, survival following VA-ECMO therapy remains low. Sex-related differences might impact the outcome of therapeutic measures. We aimed to compare all-cause mortality among female and male patients who underwent VA-ECMO as a bridge to recovery investigating sex-related differences. From January 2015 until August 2020, 87 patients were supported by VA-ECMO as a part of our out-of-center mobile ECMO program. In order to analyze sex-associated differences in early clinical outcomes, patients were divided into two sex categories: men (n = 62) and women (n = 25). All relevant data (in-hospital mortality, ICU and hospital stay, renal failure requiring dialysis, lung failure, bleeding, stroke and septic shock) were analyzed retrospectively after the extraction from our institutional database. Mean age of the study population was 53 +/- 14 years. Mean EuroSCORE II predicted mortality was 6.5 +/- 3.7. In-hospital mortality rate was not significantly lower in the female group (58.3%) vs. the male group (71.2%), p = 0.190. The mean length of ICU and hospital stay was 9 +/- 11 in the male group vs. 10 +/- 13 in the female group, p = 0.901, and 10 +/- 12 (male group) vs. 11 +/- 13 (female group), p = 0.909, respectively. Renal failure requiring hemodialysis (36.2% (males) vs. 28.6% (females), p = 0.187) was comparable between both groups. Respiratory failure was diagnosed in 31 (56.4%) male vs. 8 (34.8%) female patients, p = 0.068, while 16 (28.6%) male vs. 3 (13.0%) female patients (p = 0.118) suffered from septic shock. Based on our data, there were no sex-specific outcome discrepancies in patients treated with mobile VA-ECMO implantation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Krasivskyi, Ihor UNSPECIFIED orcid.org/0000-0003-0573-8218 UNSPECIFIED Ivanov, Borko UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehrenberg, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Eghbalzadeh, Kaveh UNSPECIFIED orcid.org/0000-0001-6941-7785 UNSPECIFIED Gerfer, Stephen UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaisendrees, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Elmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabashnikov, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Mader, Navid UNSPECIFIED UNSPECIFIED UNSPECIFIED Djordjevic, Ilija UNSPECIFIED orcid.org/0000-0002-5810-8626 UNSPECIFIED Wahlers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-662231
DOI:	10.3390/life12111746
Journal or Publication Title:	Life-Basel
Volume:	12
Number:	11
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2075-1729
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRACORPOREAL MEMBRANE-OXYGENATION; HOSPITAL CARDIAC-ARREST; LONG-TERM; LIFE-SUPPORT; RISK-FACTORS; MORTALITY; SURVIVAL; COMPLICATIONS; MYOCARDITIS; THERAPY Multiple languages Biology; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66223