Universität zu Köln

Schmidt, Sarah, Fortmeier, Vera, Ludwig, Sebastian, Wienemann, Hendrik, Koerber, Maria Isabel, Lee, Samuel ORCID: 0000-0001-6768-7079, Meertens, Max, Macherey, Sascha, Iliadis, Christos, Kuhn, Elmar, Eghbalzadeh, Kaveh, Bleiziffer, Sabine, Baldus, Stephan, Schofer, Niklas, Rudolph, Tanja Katharina, Adam, Matti and Mauri, Victor (2022). Hemodynamics of self-expanding versus balloon-expandable transcatheter heart valves in relation to native aortic annulus anatomy. Clin. Res. Cardiol., 111 (12). S. 1336 - 1348. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692

Full text not available from this repository.

Abstract

Objectives This study aimed to compare hemodynamic characteristics of different self-expanding (SE) and balloon-expandable (BE) transcatheter heart valves (THV) in relation to native aortic annulus anatomy. Background A patient centered THV selection becomes increasingly important as indications for transcatheter aortic valve replacement (TAVR) are extended towards lower risk populations. Methods Hemodynamic parameters including mean gradient (MG), effective orifice area (EOA), Doppler velocity index (DVI), degree of paravalvular regurgitation (PVR) and patient-prosthesis mismatch (PPM) were compared by valve type, label size and in relation to quintiles of native aortic annulus area. Results 2609 patients were treated at 3 centers in Germany with SAPIEN 3 (n = 1146), ACURATE Neo (n = 649), Evolut R (n = 546) or Evolut Pro (n = 268) THV. SE THVs provided superior hemodynamics in terms of larger EOA, higher DVI and lower MG compared to BE THV, especially in patients with small aortic annuli. Severe PPM was less frequent in SE treated patients. The rate of PVR >= moderate was comparable for SE and BE devices in smaller annular dimensions, but remarkably lower for BE TAVR in large aortic annular dimensions (> 547.64 mm(2)) (2% BE THV vs. > 10% for SE THV; p < 0.001). Conclusions Patients with small aortic annular dimensions may benefit hemodynamically from SE THV. With increasing annulus size, BE THV may have advantages since PVR >= moderate occurs less frequently.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Fortmeier, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Ludwig, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wienemann, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Koerber, Maria Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Samuel UNSPECIFIED orcid.org/0000-0001-6768-7079 UNSPECIFIED Meertens, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Macherey, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Iliadis, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Elmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Eghbalzadeh, Kaveh UNSPECIFIED UNSPECIFIED UNSPECIFIED Bleiziffer, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schofer, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, Tanja Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Adam, Matti UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauri, Victor UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-671357
DOI:	10.1007/s00392-022-02046-7
Journal or Publication Title:	Clin. Res. Cardiol.
Volume:	111
Number:	12
Page Range:	S. 1336 - 1348
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1861-0692
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROSTHESIS-PATIENT MISMATCH; HIGH-RISK PATIENTS; PARAVALVULAR REGURGITATION; REPLACEMENT; STENOSIS; OUTCOMES; TRIAL; IMPLANTATION; ASSOCIATION; TERM Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67135