Ehren, Rasmus, Habbig, Sandra, Krupka, Kai, Ernst, Angela ORCID: 0000-0003-2375-1889, Bald, Martin, Koenig, Sabine, Murer, Luisa, Ozcakar, Zeynep Birsin, Pohl, Michael, Babenko, Nadezhda, Sparta, Giuseppina, Staude, Hagen, Dello Strologo, Luca, Szabo, Attila J., Tonshoff, Burkhard and Weber, Lutz T. (2022). Prevalence and potential relevance of hyperuricemia in pediatric kidney transplant recipients-a CERTAIN registry analysis. Pediatr. Transplant., 26 (4). HOBOKEN: WILEY. ISSN 1399-3046

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Abstract

Background Asymptomatic hyperuricemia is frequently observed in pediatric kidney transplant recipients; symptomatic hyperuricemia, however, is a rare complication. Only few data are available in this patient population. We, therefore, investigated the prevalence of hyperuricemia and its association with kidney transplant function and blood pressure in a multicenter cohort of pediatric kidney transplant recipients. Methods This is a retrospective, observational multicenter registry study. All pediatric kidney transplant recipients in the CERTAIN database with at least one documented serum uric acid level and a follow-up of 5 years posttransplant were eligible. We identified 151 patients with 395 measurements of serum uric acid. We calculated the prevalence of hyperuricemia, analyzed potential risk factors and clinical consequences such as elevated blood pressure and reduced estimated glomerular filtration rate (eGFR). Statistical analysis was performed using IBM SPSS Statistics 26. Results One hundred and ten of 395 (27.8%) serum uric acid levels were above 416 mu mol/L (7.0 mg/dL), defined as the upper limit of normal. Univariate analysis showed a significant (p = .026) inverse association of serum uric acid with eGFR overtime. There was no significant association of serum uric acid concentrations with body mass index (z-score), blood pressure (z-score), or sex. No episodes of gout were documented. Conclusion This study shows that hyperuricemia is present in a considerable number of patients sometime after pediatric kidney transplantation and is associated with lower eGFR. Whether hyperuricemia contributes to faster decline of graft function or to the overall cardiovascular risk of these patients remains to be elucidated.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ehren, RasmusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Habbig, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krupka, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ernst, AngelaUNSPECIFIEDorcid.org/0000-0003-2375-1889UNSPECIFIED
Bald, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murer, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ozcakar, Zeynep BirsinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pohl, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Babenko, NadezhdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sparta, GiuseppinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Staude, HagenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dello Strologo, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szabo, Attila J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tonshoff, BurkhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, Lutz T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-693587
DOI: 10.1111/petr.14265
Journal or Publication Title: Pediatr. Transplant.
Volume: 26
Number: 4
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1399-3046
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WEB-BASED REGISTRY; URIC-ACID LEVELS; ASYMPTOMATIC HYPERURICEMIA; RENAL-TRANSPLANTATION; BLOOD-PRESSURE; RISK-FACTORS; PROGRESSION; CYCLOSPORINE; GOUT; ALLOPURINOLMultiple languages
Pediatrics; TransplantationMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69358

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