Universität zu Köln

Goepel, Wolfgang, Kribs, Angela, Roll, Claudia, Wieg, Christian, Teig, Norbert, Hoehn, Thomas, Welzing, Lars, Vochem, Matthias, Hoppenz, Marc, Buehrer, Christoph, Mehler, Katrin, Hubert, Mechthild, Eichhorn, Joachim, Schmidtke, Susanne, Rausch, Tanja Katrin, Koenig, Inke Regina, Haertel, Christoph, Roth, Bernd and Herting, Egbert (2022). Multi-centre randomised trial of invasive and less invasive surfactant delivery methods showed similar spirometry results at 5-9 years of age. Acta Paediatr., 111 (11). S. 2108 - 2115. HOBOKEN: WILEY. ISSN 1651-2227

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Abstract

Aim We explored whether subnormal forced expiratory volume within 1 s (FEV1) at 5-9 years of age was lower in children born preterm who received less invasive surfactant administration (LISA) rather than surfactant via an endotracheal tube. Methods The multi-centre, randomised Nonintubated Surfactant Application trial enrolled 211 preterm infants born at 23-26 weeks of gestation from 13 level III neonatal intensive care units from April 2009 to March 2012. They received surfactant via LISA (n = 107) or after conventional endotracheal intubation (n = 104). The follow-up assessments were carried out by a single team blinded to the group assignments. The main outcome was FEV1 < 80% of predicted values. Results Spirometry was successful in 102/121 children. The other children died or were lost to follow-up. Median FEV1 was 93% (interquartile range 80%-113%) of predicted values in the LISA group and 86% (interquartile range 77-102%) in the control group (p = 0.685). Rates of FEV1 < 80% were 11/57 (19%) and 15/45 (33%), respectively, which was an absolute risk reduction of 14% (95% confidence interval -3.1% to 31.2%, p = 0.235). There were no differences in other outcome measures. Conclusion The proportion of children aged 5-9 years with subnormal FEV1 was not significantly different between the groups.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goepel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Kribs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Roll, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Teig, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoehn, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Welzing, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Vochem, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppenz, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Buehrer, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Mehler, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hubert, Mechthild UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichhorn, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidtke, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Rausch, Tanja Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Inke Regina UNSPECIFIED UNSPECIFIED UNSPECIFIED Haertel, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Roth, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Herting, Egbert UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-694553
DOI:	10.1111/apa.16499
Journal or Publication Title:	Acta Paediatr.
Volume:	111
Number:	11
Page Range:	S. 2108 - 2115
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1651-2227
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-FREQUENCY OSCILLATION; EXTREMELY PRETERM INFANTS; LUNG-FUNCTION; OUTCOMES; VENTILATION Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69455