Pinto, Serge ORCID: 0000-0002-3375-4787, Nebel, Adelheid, Rau, Jorn, Espesser, Robert, Maillochon, Pauline, Niebuhr, Oliver ORCID: 0000-0002-8623-1680, Krack, Paul ORCID: 0000-0002-3508-7295, Witjas, Tatiana, Ghio, Alain ORCID: 0000-0001-7302-0799, Cuartero, Marie-Charlotte, Timmermann, Lars, Schnitzler, Alfons ORCID: 0000-0002-6414-7939, Hesekamp, Helke, Meier, Niklaus, Muellner, Julia, Haelbig, Thomas D., Moeller, Bettina, Paschen, Steffen, Paschen, Laura, Volkmann, Jens, Barbe, Michael T., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Becker, Johannes, Reker, Paul, Kuehn, Andrea A., Schneider, Gerd-Helge ORCID: 0000-0002-1301-2938, Fraix, Valerie, Seigneuret, Eric, Kistner, Andrea, Rascol, Olivier, Brefel-Courbon, Christine, Ory-Magne, Fabienne, Hartmann, Christian J., Wojtecki, Lars, Fradet, Anne, Maltete, David, Damier, Philippe, Le Dily, Severine, Sixel-Doering, Friederike, Benecke, Petra, Weiss, Daniel, Waechter, Tobias, Pinsker, Marcus O., Regis, Jean, Thobois, Stephane, Polo, Gustavo, Houeto, Jean-Luc, Hartmann, Andreas, Knudsen, Karina, Vidailhet, Marie, Schuepbach, Michael and Deuschl, Gunther . Results of a Randomized Clinical Trial of Speech after Early Neurostimulation in Parkinson's Disease. Mov. Disord.. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

BackgroundThe EARLYSTIM trial demonstrated for Parkinson's disease patients with early motor complications that deep brain stimulation of the subthalamic nucleus (STN-DBS) and best medical treatment (BMT) was superior to BMT alone. ObjectiveThis prospective, ancillary study on EARLYSTIM compared changes in blinded speech intelligibility assessment between STN-DBS and BMT over 2 years, and secondary outcomes included non-speech oral movements (maximum phonation time [MPT], oral diadochokinesis), physician- and patient-reported assessments. MethodsSTN-DBS (n = 102) and BMT (n = 99) groups underwent assessments on/off medication at baseline and 24 months (in four conditions: on/off medication, ON/OFF stimulation-for STN-DBS). Words and sentences were randomly presented to blinded listeners, and speech intelligibility rate was measured. Statistical analyses compared changes between the STN-DBS and BMT groups from baseline to 24 months. ResultsOver the 2-year period, changes in speech intelligibility and MPT, as well as patient-reported outcomes, were not different between groups, either off or on medication or OFF or ON stimulation, but most outcomes showed a nonsignificant trend toward worsening in both groups. Change in oral diadochokinesis was significantly different between STN-DBS and BMT groups, on medication and OFF STN-DBS, with patients in the STN-DBS group performing slightly worse than patients under BMT only. A signal for clinical worsening with STN-DBS was found for the individual speech item of the Unified Parkinson's Disease Rating Scale, Part III. ConclusionAt this early stage of the patients' disease, STN-DBS did not result in a consistent deterioration in blinded speech intelligibility assessment and patient-reported communication, as observed in studies of advanced Parkinson's Disease. (c) 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pinto, SergeUNSPECIFIEDorcid.org/0000-0002-3375-4787UNSPECIFIED
Nebel, AdelheidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rau, JornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espesser, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maillochon, PaulineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niebuhr, OliverUNSPECIFIEDorcid.org/0000-0002-8623-1680UNSPECIFIED
Krack, PaulUNSPECIFIEDorcid.org/0000-0002-3508-7295UNSPECIFIED
Witjas, TatianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghio, AlainUNSPECIFIEDorcid.org/0000-0001-7302-0799UNSPECIFIED
Cuartero, Marie-CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schnitzler, AlfonsUNSPECIFIEDorcid.org/0000-0002-6414-7939UNSPECIFIED
Hesekamp, HelkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meier, NiklausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muellner, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haelbig, Thomas D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeller, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paschen, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paschen, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volkmann, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbe, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Becker, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reker, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuehn, Andrea A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, Gerd-HelgeUNSPECIFIEDorcid.org/0000-0002-1301-2938UNSPECIFIED
Fraix, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seigneuret, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kistner, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rascol, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brefel-Courbon, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ory-Magne, FabienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, Christian J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wojtecki, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fradet, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maltete, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Damier, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Dily, SeverineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sixel-Doering, FriederikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benecke, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waechter, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinsker, Marcus O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regis, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thobois, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polo, GustavoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houeto, Jean-LucUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knudsen, KarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidailhet, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuepbach, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, GuntherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698087
DOI: 10.1002/mds.29282
Journal or Publication Title: Mov. Disord.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1531-8257
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEEP-BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS STIMULATION; OUTCOMES; INTELLIGIBILITY; INDIVIDUALS; DYSARTHRIA; VALIDATION; DISORDERS; MOVEMENT; PATIENTMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69808

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