Ferreri, Andres J. M., Cwynarski, Kate, Pulczynski, Elisa, Fox, Christopher P., Schorb, Elisabeth, Celico, Claudia, Falautano, Monica, Nonis, Alessandro, La Rosee, Paul ORCID: 0000-0002-6758-7809, Binder, Mascia, Fabbri, Alberto, Ilariucci, Fiorella, Krampera, Mauro, Roth, Alexander, Hemmaway, Claire, Johnson, Peter W., Linton, Kim M., Pukrop, Tobias, Gorlov, Jettes Sonderskov, Balzarotti, Monica, Hess, Georg, Keller, Ulrich, Stilgenbauer, Stephan, Panse, Jense, Tucci, Alessandra, Orsucci, Lorella, Pisani, Francesco, Zanni, Manuela, Krause, Stefan W., Schmoll, Hans J., Hertenstein, Bernd, Rummel, Mathias, Smith, Jeffery, Thurner, Lorenz, Cabras, Giuseppina, Pennese, Elsa, Ponzoni, Maurilio, Deckert, Martina, Politi, Letterio S., Finke, Jurgen, Ferranti, Antonella, Cozens, Kelly, Burger, Elvira, Ielmini, Nicoletta, Cavalli, Franco, Zucca, Emanuele and Illerhaus, Gerald (2022). Long-term efficacy, safety and neurotolerability of MATRix regimen followed by autologous transplant in primary CNS lymphoma: 7-year results of the IELSG32 randomized trial. Leukemia, 36 (7). S. 1870 - 1879. LONDON: SPRINGERNATURE. ISSN 1476-5551

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Abstract

219 HIV-negative adults <= 70 years with primary CNS lymphoma (PCNSL) were enrolled in the randomized IELSG32 trial. Enrolled patients were randomly assigned to receive methotrexate-cytarabine (arm A), or methotrexate-cytarabine-rituximab (B), or methotrexate-cytarabine-thiotepa-rituximab (MATRix; arm C). A second randomization allocated patients with responsive/stable disease to whole-brain irradiation (WBRT) or carmustine-thiotepa-conditioned autologous transplantation (ASCT). First results, after a median follow-up of 30 months, showed that MATRix significantly improves outcome, with both WBRT and ASCT being similarly effective. However, sound assessment of overall survival (OS), efficacy of salvage therapy, late complications, secondary tumors, and cognitive impairment requires longer follow-up. Herein, we report the results of this trial at a median follow-up of 88 months. As main findings, MATRix was associated with excellent long-lasting outcome, with a 7-year OS of 21%, 37%, and 56% respectively for arms A, B, and C. Notably, patients treated with MATRix and consolidation had a 7-year OS of 70%. The superiority of arm B on arm A suggests a benefit from the addition of rituximab. Comparable efficacy of WBRT and ASCT was confirmed. Salvage therapy was ineffective; benefit was recorded only in patients with late relapse re-treated with methotrexate. Eight (4%) patients developed a second cancer. Importantly, MATRix and ASCT did not result in higher non-relapse mortality or second tumors incidence. Patients who received WBRT experienced impairment in attentiveness and executive functions, whereas patients undergoing ASCT experienced improvement in these functions as well as in memory and quality of life.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ferreri, Andres J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cwynarski, KateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pulczynski, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fox, Christopher P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schorb, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Celico, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falautano, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nonis, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
La Rosee, PaulUNSPECIFIEDorcid.org/0000-0002-6758-7809UNSPECIFIED
Binder, MasciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fabbri, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ilariucci, FiorellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krampera, MauroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roth, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemmaway, ClaireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, Peter W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linton, Kim M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pukrop, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gorlov, Jettes SonderskovUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balzarotti, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hess, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keller, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stilgenbauer, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panse, JenseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tucci, AlessandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orsucci, LorellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pisani, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zanni, ManuelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krause, Stefan W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmoll, Hans J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hertenstein, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rummel, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, JefferyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thurner, LorenzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cabras, GiuseppinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pennese, ElsaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ponzoni, MaurilioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deckert, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Politi, Letterio S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finke, JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferranti, AntonellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cozens, KellyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burger, ElviraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ielmini, NicolettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavalli, FrancoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zucca, EmanueleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Illerhaus, GeraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698899
DOI: 10.1038/s41375-022-01582-5
Journal or Publication Title: Leukemia
Volume: 36
Number: 7
Page Range: S. 1870 - 1879
Date: 2022
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1476-5551
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STEM-CELL TRANSPLANTATION; INTERNATIONAL EXTRANODAL LYMPHOMA; NERVOUS-SYSTEM LYMPHOMA; HIGH-DOSE CHEMOTHERAPY; WHOLE-BRAIN RADIATION; COGNITIVE FUNCTIONS; METHOTREXATE; CHEMOIMMUNOTHERAPY; SINGLE; RISKMultiple languages
Oncology; HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69889

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