Universität zu Köln

Reissmann, Bruno, Plenge, Tobias, Heeger, Christian-Hendrik, Schlueter, Michael, Wohlmuth, Peter, Fink, Thomas, Rottner, Laura, Tilz, Roland Richard, Mathew, Shibu, Lemes, Christine, Maurer, Tilman, Lueker, Jakob, Sultan, Arian, Bellmann, Barbara, Goldmann, Britta, Ouyang, Feifan, Kuck, Karl-Heinz, Metzner, Andreas, Steven, Daniel and Rillig, Andreas (2019). Predictors of freedom from atrial arrhythmia recurrence after cryoballoon ablation for persistent atrial fibrillation: A multicenter study. J. Cardiovasc. Electrophysiol., 30 (9). S. 1436 - 1443. HOBOKEN: WILEY. ISSN 1540-8167

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Abstract

Aims We sought to assess (1) clinical outcomes of second-generation cryoballoon (CB) ablation for persistent atrial fibrillation (AF), and (2) the association of baseline and procedural covariates with atrial arrhythmia recurrence (AAR) after ablation. Methods A total of 135 patients (63 +/- 11 years, 96 men [71%]) with persistent AF underwent CB ablation at three experienced electrophysiology centers. Freedom from AAR was estimated with the Kaplan-Meier method. A Cox proportional-hazards model was used to estimate the effects of baseline and procedural covariates on the likelihood of AAR. Results Freedom from AAR at 6, 12, and 18 months was estimated at 91% (95% confidence interval [CI] 86%-96%), 75% (95% CI, 67%-83%), and 53% (95% CI, 43%-65%), respectively. The presence of an implantable cardiac device (Hazard ratio [HR] 3.09; 95% CI, 1.37-7.00; P = .007), a left atrial (LA) diameter > 50 mm (HR 1.69; 95% CI, 1.02-2.79; P = .043), and absence of antiarrhythmic drug (AAD) therapy before the ablation procedure (HR 3.12; 95% CI, 1.72-5.64; P < .001) were associated with AAR. A trend toward an increased risk of AAR was revealed for women (HR 1.73; 95% CI, 0.96-3.11; P = .069). Conclusions CB ablation for persistent AF resulted in freedom from AAR about that reported for RF ablation. The presence of an implantable cardiac device, LA size, and absence of AAD therapy at baseline were associated with the risk of AAR.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reissmann, Bruno UNSPECIFIED UNSPECIFIED UNSPECIFIED Plenge, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Heeger, Christian-Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlueter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlmuth, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rottner, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Tilz, Roland Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathew, Shibu UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemes, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Maurer, Tilman UNSPECIFIED UNSPECIFIED UNSPECIFIED Lueker, Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Sultan, Arian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bellmann, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldmann, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Ouyang, Feifan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuck, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzner, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Rillig, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-135697
DOI:	10.1111/jce.14023
Journal or Publication Title:	J. Cardiovasc. Electrophysiol.
Volume:	30
Number:	9
Page Range:	S. 1436 - 1443
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1540-8167
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PULMONARY VEIN ISOLATION; CATHETER ABLATION; 2ND-GENERATION CRYOBALLOON; RADIOFREQUENCY ABLATION; SUCCESS Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13569