Hu, Xiaochen, Teunissen, Charlotte E., Spottke, Annika, Heneka, Michael T., Duezel, Emrah, Peters, Oliver, Li, Siyao, Priller, Josef ORCID: 0000-0001-7596-0979, Buerger, Katharina, Teipel, Stefan, Laske, Christoph, Verfaillie, Sander C. J., Barkhof, Frederik ORCID: 0000-0003-3543-3706, Coll-Padros, Nina ORCID: 0000-0002-9282-6701, Rami, Lorena, Molinuevo, Jose Luis, van der Flier, Wiesje M. and Jessen, Frank (2019). Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease-Data from three memory clinic studies. Alzheimers. Dement., 15 (2). S. 185 - 194. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1552-5279

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Abstract

Introduction: Previous studies showed associations of brain volume differences and biomarker evidence for Alzheimer's disease (AD) in subjective cognitive decline (SCD). The consistency of this finding across SCD studies has not been investigated. Methods: We studied gray matter volume differences between SCD subjects with and without cerebrospinal fluid biomarker evidence for AD across three European memory clinic samples (German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia study, Amsterdam, Barcelona). Analysis of covariance models with samples and cerebrospinal fluid biomarkers as between-subject factors were calculated. Results: A significant main effect for AD biomarker (A beta(422)- > A beta(42)+) in the left medial temporal lobe (MTL) was found, with the absence of main effects for sample or interaction effects between AD biomarker and sample. This indicates consistent lower left MTL volume across three samples in SCD subjects with abnormal A beta(42) levels. Discussion: Our results support the model that in the presence of AD pathology, SCD corresponds to the late preclinical stage (stage 2 of AD) with smaller MTL volumes. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hu, XiaochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teunissen, Charlotte E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duezel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, SiyaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDorcid.org/0000-0001-7596-0979UNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teipel, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laske, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verfaillie, Sander C. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barkhof, FrederikUNSPECIFIEDorcid.org/0000-0003-3543-3706UNSPECIFIED
Coll-Padros, NinaUNSPECIFIEDorcid.org/0000-0002-9282-6701UNSPECIFIED
Rami, LorenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Molinuevo, Jose LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Flier, Wiesje M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-158035
DOI: 10.1016/j.jalz.2018.09.002
Journal or Publication Title: Alzheimers. Dement.
Volume: 15
Number: 2
Page Range: S. 185 - 194
Date: 2019
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1552-5279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
AMYLOID DEPOSITION; EPISODIC MEMORY; OLDER-ADULTS; DEPRESSION SCALE; MILD; BETA; IMPAIRMENT; DEMENTIA; ASSOCIATION; PREVENTIONMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15803

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