Spahn, Ingo (2006). Radiochemical Studies Related to the Development of New Production Routes of some Diagnostic and Therapeutic Radionuclides. PhD thesis, Universität zu Köln.

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Abstract

Nuclear reaction cross section measurements were done in connection with the development of new production routes of the therapeutic and diagnostic radionuclides P-32, As-71, As-72, As-73, As-74, Sr-82, Y-90, Sm-153 and Yb-169. Investigations on the production of n.c.a. Se-73 using novel targetry were also performed. Integral cross sections were measured for the S-nat(n,p)P-32, Zr-nat(n,p)Y-90 and Eu-nat(n,p)Sm-153 reactions using a 14 MeV d(Be) neutron field. The neutron spectrum was characterised using multiple foil activation and the code SULSA. Existing cross section data were validated within 10 - 15 %, thereby substantiating earlier evaluated and recommended excitation functions of the investigated reactions. It is inferred that for production of radionuclides via the (n,p) reaction, a fast neutron spectral source (e.g. spallation or fusion) would be better suited than a fission reactor. Proton and alpha particle induced reactions were investigated in the high-mass area for the production of Sm-153 and Yb-169 via alternative routes. Measurements were done for the first time on the Nd-nat(alpha,n)Sm-153 process over the energy range of 10 to 26.5 MeV and the possible production yield of Sm-153 amounts to 2 GBq. The excitation function of the Tm-169(p,n)Yb-169 reaction was determined over the energy range from threshold to 45 MeV and compared with the results of nuclear model calculation based on the ALICE-IPPE code. A good agreement was found. The calculated possible production yields are lower than those via the conventional (n,gamma) production route, but the produced Sm-153 and Yb-169 are in no-carrier-added form. Cross sections were also measured with regard to the production of As-71, As-72, As-73 and As-74 via the Ge-nat(p,xn) processes and the results were compared with those from the ALICE-IPPE calculations. Possible yields were calculated together with potential impurities. The various processes contributing to the formation of As-71 in the irradiation of Ge-nat were analysed by performing some additional measurements on enriched Ge-72. For the standardisation and validation of data for the production of Sr-82 via the Rb-nat(p,xn) process, cross section measurements on the formation of the long-lived impurity Sr-85 were done over the energy range of 25 to 45 MeV, a range where a gap still existed. Integral yields were calculated, allowing for an evaluation of the best production conditions of Sr-82. Preliminary studies on the production of n.c.a. Se-73 via the As-75(p,xn) reaction using AlAs as a novel target material were also carried out. Thick target yields were determined and first tests on the radiochemical separation of n.c.a. radioselenium from the target were performed.

Item Type: Thesis (PhD thesis)
Translated title:
TitleLanguage
Radiochemische Untersuchungen für die Entwicklung neuer Produktionswege einiger diagnostischer und therapeutischer RadionuklideGerman
Creators:
CreatorsEmailORCID
Spahn, Ingoi.spahn@fz-juelich.deUNSPECIFIED
URN: urn:nbn:de:hbz:38-19898
Subjects: Chemistry and allied sciences
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Institute of Nuclear Chemistry
Language: English
Date: 2006
Date of oral exam: 12 February 2007
Referee:
NameAcademic Title
Qaim, Syed M.Prof. Dr. Dr. h.c.
Full Text Status: Public
Date Deposited: 11 Apr 2007 11:29
URI: http://kups.ub.uni-koeln.de/id/eprint/1989

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