Richter, Nils ORCID: 0000-0002-3377-5684, Michel, Anne, Onur, Oezguer A., Kracht, Lutz, Dietlein, Markus, Tittgemeyer, Marc, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Kukolja, Juraj ORCID: 0000-0003-1569-3287 (2017). White matter lesions and the cholinergic deficit in aging and mild cognitive impairment. Neurobiol. Aging, 53. S. 27 - 36. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-1497

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Abstract

In Alzheimer's disease (AD), white matter lesions (WMLs) are associated with an increased risk of progression from mild cognitive impairment (MCI) to dementia, while memory deficits have, at least in part, been linked to a cholinergic deficit. We investigated the relationship betweenWMLload assessed with the Scheltens scale, cerebral acetylcholinesterase (AChE) activity measured with [C-11] N-methyl-4-piperidyl acetate PET, and neuropsychological performance in 17 patients with MCI due to AD and 18 cognitively normal older participants. Only periventricular, not nonperiventricular, WML load negatively correlated with AChE activity in both groups. Memory performance depended on periventricular and total WML load across groups. Crucially, AChE activity predicted memory function better than WML load, gray matter atrophy, or age. The effects ofWMLload on memory were fully mediated byAChE activity. Data suggest that the contribution of WML to the dysfunction of the cholinergic system in MCI due to AD depends on WML distribution. Pharmacologic studies are warranted to explore whether this influences the response to cholinergic treatment. (C) 2017 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Richter, NilsUNSPECIFIEDorcid.org/0000-0002-3377-5684UNSPECIFIED
Michel, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Onur, Oezguer A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kracht, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dietlein, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tittgemeyer, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, BerndUNSPECIFIEDorcid.org/0000-0001-5425-3116UNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Kukolja, JurajUNSPECIFIEDorcid.org/0000-0003-1569-3287UNSPECIFIED
URN: urn:nbn:de:hbz:38-233481
DOI: 10.1016/j.neurobiolaging.2017.01.012
Journal or Publication Title: Neurobiol. Aging
Volume: 53
Page Range: S. 27 - 36
Date: 2017
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1558-1497
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ACETYLCHOLINE ESTERASE-ACTIVITY; POSITRON-EMISSION-TOMOGRAPHY; PROBABLE ALZHEIMERS-DISEASE; EPISODIC MEMORY; CEREBROVASCULAR-DISEASE; BASAL FOREBRAIN; NEURAL ACTIVITY; IN-VIVO; HYPERINTENSITIES; DEMENTIAMultiple languages
Geriatrics & Gerontology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23348

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