Richter, Nils ORCID: 0000-0002-3377-5684, Michel, Anne, Onur, Oezguer A., Kracht, Lutz, Dietlein, Markus, Tittgemeyer, Marc, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Kukolja, Juraj ORCID: 0000-0003-1569-3287 (2017). White matter lesions and the cholinergic deficit in aging and mild cognitive impairment. Neurobiol. Aging, 53. S. 27 - 36. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-1497
Full text not available from this repository.Abstract
In Alzheimer's disease (AD), white matter lesions (WMLs) are associated with an increased risk of progression from mild cognitive impairment (MCI) to dementia, while memory deficits have, at least in part, been linked to a cholinergic deficit. We investigated the relationship betweenWMLload assessed with the Scheltens scale, cerebral acetylcholinesterase (AChE) activity measured with [C-11] N-methyl-4-piperidyl acetate PET, and neuropsychological performance in 17 patients with MCI due to AD and 18 cognitively normal older participants. Only periventricular, not nonperiventricular, WML load negatively correlated with AChE activity in both groups. Memory performance depended on periventricular and total WML load across groups. Crucially, AChE activity predicted memory function better than WML load, gray matter atrophy, or age. The effects ofWMLload on memory were fully mediated byAChE activity. Data suggest that the contribution of WML to the dysfunction of the cholinergic system in MCI due to AD depends on WML distribution. Pharmacologic studies are warranted to explore whether this influences the response to cholinergic treatment. (C) 2017 Elsevier Inc. All rights reserved.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-233481 | ||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1016/j.neurobiolaging.2017.01.012 | ||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Neurobiol. Aging | ||||||||||||||||||||||||||||||||||||||||
Volume: | 53 | ||||||||||||||||||||||||||||||||||||||||
Page Range: | S. 27 - 36 | ||||||||||||||||||||||||||||||||||||||||
Date: | 2017 | ||||||||||||||||||||||||||||||||||||||||
Publisher: | ELSEVIER SCIENCE INC | ||||||||||||||||||||||||||||||||||||||||
Place of Publication: | NEW YORK | ||||||||||||||||||||||||||||||||||||||||
ISSN: | 1558-1497 | ||||||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/23348 |
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